C57BL/6JCya-Lipgem1/Cya
Common Name:
Lipg-KO
Product ID:
S-KO-20019
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Lipg-KO
Strain ID
KOCMP-16891-Lipg-B6J-VB
Gene Name
Product ID
S-KO-20019
Gene Alias
3110013K01Rik; EL; lipase; mEDL
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lipgem1/Cya mice (Catalog S-KO-20019) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000066532
NCBI RefSeq
NM_010720
Target Region
Exon 2~3
Size of Effective Region
~2.9 kb
Detailed Document
Overview of Gene Research
Lipg, also known as endothelial lipase (EL), is a crucial gene in the human body. It functions predominantly as a phospholipase with low levels of triglyceride lipase activity. Lipg plays an essential role in lipoprotein metabolism and is involved in metabolic syndromes such as the inflammatory response and atherosclerosis [1].
In breast cancer, studies have shown that the risk of breast cancer increases with increasing levels of LIPG, especially in pre-menopausal, Luminal A, HER2-negative, non-postpartum breast cancers, and in women with high total cholesterol levels [2]. LIPG-promoted lipid storage can mediate adaptation to oxidative stress in breast cancer cells, and high LIPG expression is associated with shorter metastasis-free survival in node-negative, untreated breast cancer patients [3].
In lung adenocarcinoma, LIPG expression is higher in tumor tissues, especially in certain patient subgroups, and high expression predicts a poor prognosis. It may affect the development of lung adenocarcinoma through lipid metabolism and immune system regulation, and is correlated with immune infiltrates and response to antitumor drugs [4].
In colorectal cancer, ZDHHC1 can downregulate LIPG and inhibit cancer cell growth [5].
In human basal-like triple-negative breast cancer, LIPG is overexpressed and is required for tumorigenicity and metastasis, and its phospholipase activity can be targeted to suppress tumor formation [6,7]. Additionally, in some ethnic groups, LIPG SNPs and their haplotypes are associated with serum lipid levels [8].
In conclusion, Lipg is involved in multiple biological processes, especially lipoprotein metabolism and related metabolic syndromes. Its role in various cancers, such as breast, lung, and colorectal cancers, has been increasingly recognized through research. The study of Lipg using different models helps to understand its function in disease development, providing potential targets for cancer treatment and management of metabolic diseases.
References:
1. Hong, Chang, Deng, Ruxia, Wang, Ping, Cai, Rui, Lin, Jie. 2020. LIPG: an inflammation and cancer modulator. In Cancer gene therapy, 28, 27-32. doi:10.1038/s41417-020-0188-5. https://pubmed.ncbi.nlm.nih.gov/32572177/
2. Gago-Dominguez, Manuela, Redondo, Carmen M, Calaza, Manuel, Carracedo, Ángel, Castelao, J Esteban. 2021. LIPG endothelial lipase and breast cancer risk by subtypes. In Scientific reports, 11, 10436. doi:10.1038/s41598-021-89669-4. https://pubmed.ncbi.nlm.nih.gov/34001944/
3. Cadenas, Cristina, Vosbeck, Sonja, Edlund, Karolina, Marchan, Rosemarie, Hengstler, Jan G. 2019. LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer. In International journal of cancer, 145, 901-915. doi:10.1002/ijc.32138. https://pubmed.ncbi.nlm.nih.gov/30653260/
4. Wang, Shan, Chen, Zhaoxin, Lv, Hongwei, Wei, Huamin, Yu, Jing. 2022. LIPG is a novel prognostic biomarker and correlated with immune infiltrates in lung adenocarcinoma. In Journal of clinical laboratory analysis, 37, e24824. doi:10.1002/jcla.24824. https://pubmed.ncbi.nlm.nih.gov/36572999/
5. Zhang, Qun, Du, Zhouyuan, Zhou, Wei, Yu, Haixin, Liu, Tao. 2024. ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation. In Cancer gene therapy, 31, 1427-1437. doi:10.1038/s41417-024-00808-1. https://pubmed.ncbi.nlm.nih.gov/39069526/
6. Lo, Pang-Kuo, Yao, Yuan, Lee, Ji Shin, Kane, Maureen A, Zhou, Qun. 2018. LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer. In eLife, 7, . doi:10.7554/eLife.31334. https://pubmed.ncbi.nlm.nih.gov/29350614/
7. Lo, Pang-Kuo, Yao, Yuan, Zhou, Qun. 2020. Inhibition of LIPG phospholipase activity suppresses tumor formation of human basal-like triple-negative breast cancer. In Scientific reports, 10, 8911. doi:10.1038/s41598-020-65400-7. https://pubmed.ncbi.nlm.nih.gov/32488004/
8. Yang, Shuo, Yin, Rui-Xing, Miao, Liu, Wu, Jie, Zhang, Qing-Hui. 2019. LIPG SNPs, their haplotypes and gene-environment interactions on serum lipid levels. In Lipids in health and disease, 18, 10. doi:10.1186/s12944-018-0942-y. https://pubmed.ncbi.nlm.nih.gov/30621702/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen