C57BL/6JCya-Adgre1em1/Cya
Common Name
Adgre1-KO
Product ID
S-KO-20027
Backgroud
C57BL/6JCya
Strain ID
KOCMP-13733-Adgre1-B6J-VC
When using this mouse strain in a publication, please cite “Adgre1-KO Mouse (Catalog S-KO-20027) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Adgre1-KO
Strain ID
KOCMP-13733-Adgre1-B6J-VC
Gene Name
Product ID
S-KO-20027
Gene Alias
DD7A5-7, EGF-TM7, Emr1, F4/80, Gpf480, Ly71, TM7LN3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000086763
NCBI RefSeq
NM_010130
Target Region
Exon 10
Size of Effective Region
~0.8 kb
Overview of Gene Research
Adgre1, also known as EMR1 and F4/80, is an adhesion G protein-coupled receptor. It is a myeloid differentiation marker expressed in mammalian monocyte-macrophages [1]. The gene has an extracellular domain with repeated Epidermal Growth Factor (EGF)-like calcium-binding domains, and its expression can be induced by macrophage colony-stimulating factor (CSF1) [1].
In the context of diseases, in colon cancer, tumor-associated macrophages (TAMs) can upregulate EMR1 (ADGRE1) in cancer cells. This upregulation promotes colon cancer progression by activating the JAK2/STAT1,3 signaling pathway, increasing cell proliferation, migration, and motility, and reducing apoptosis [2]. Also, EMR1-TC (EMR1 expression in tumor cells) is a high-risk factor for lymph node metastasis and is related to poor recurrence-free survival, especially in patients with TAM-rich colorectal cancer [3].
In conclusion, Adgre1 is a key marker in monocyte-macrophages. Its dysregulation in cancer, as revealed by in-vitro co-culture and immunohistochemical studies, plays a significant role in colon and colorectal cancer progression. Understanding Adgre1's function provides insights into the molecular mechanisms of cancer development and may offer potential therapeutic targets.
References：
1. Waddell, Lindsey A, Lefevre, Lucas, Bush, Stephen J, Hope, Jayne C, Hume, David A. 2018. ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages. In Frontiers in immunology, 9, 2246. doi:10.3389/fimmu.2018.02246. https://pubmed.ncbi.nlm.nih.gov/30327653/
2. Akter, Rokeya, Park, Rackhyun, Lee, Soo Kyung, Park, Junsoo, Cho, Mee-Yon. 2024. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. In International journal of molecular sciences, 25, . doi:10.3390/ijms25084388. https://pubmed.ncbi.nlm.nih.gov/38673975/
3. Akter, Rokeya, Kim, Kwangmin, Kwon, Hye Youn, Cho, Hye-Mi, Cho, Mee-Yon. 2022. EMR1/ADGRE1 Expression in Cancer Cells Upregulated by Tumor-Associated Macrophages Is Related to Poor Prognosis in Colorectal Cancer. In Biomedicines, 10, . doi:10.3390/biomedicines10123121. https://pubmed.ncbi.nlm.nih.gov/36551877/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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