C57BL/6JCya-Batf2em1/Cya
Common Name
Batf2-KO
Product ID
S-KO-20232
Backgroud
C57BL/6JCya
Strain ID
KOCMP-74481-Batf2-B6J-VB
Status
When using this mouse strain in a publication, please cite “Batf2-KO Mouse (Catalog S-KO-20232) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Batf2-KO
Strain ID
KOCMP-74481-Batf2-B6J-VB
Gene Name
Product ID
S-KO-20232
Gene Alias
B-ATF-2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19 (Mouse)
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Transcript ID
ENSMUST00000045042
NCBI Transcript ID
NM_028967
Target Region
Exon 3
Size of Effective Region
~2.6 kb
Overview of Gene Research
BATF2, also known as basic leucine zipper ATF-like transcription factor 2, is a transcription factor emerging as an important regulator in both the innate immune system and cancer-related processes. It is involved in various signaling pathways such as PTEN/AKT/β-catenin, PI3K-AKT, and is associated with interferon-activated immune response [1,3,4,6]. In the immune system, it impacts pro-inflammatory cytokine responses, and in cancer, it can act as a tumor suppressor [1,3,5,6,7]. Genetic models, especially KO mouse models, have been crucial in studying its functions.
In gastric cancer, BATF2 overexpression increased 5-Fu sensitivity, inhibited the ABCG2 drug transporter, and reduced the stem-like properties of cancer cells through the PTEN/AKT/β-catenin pathway, highlighting its role in regulating chemoresistance [1]. In glioblastoma multiforme, BATF2 inhibited glioma growth and myeloid-derived suppressor cells (MDSCs) recruitment. BATF2-overexpressing glioma cell-derived extracellular vesicles inhibited MDSCs chemotaxis, and the abundance of BATF2-positive extracellular vesicles in plasma could distinguish different stages of glioma [2]. In non-small cell lung cancer, BATF2 knockout mice studies showed that BATF2 inhibits programmed death-ligand 1 expression via the PI3K-AKT pathway and enhances CD8+ T-cell infiltration, suggesting its potential as a biomarker for immunotherapy efficacy [6].
In summary, BATF2 plays essential roles in the immune response and cancer development. Model-based research, particularly KO mouse models, has revealed its significance in diseases like gastric cancer, glioblastoma, and non-small cell lung cancer. It is involved in regulating chemoresistance, tumor growth, immune cell recruitment, and immune checkpoint molecule expression, providing insights for potential therapeutic strategies.
References：
1. Cao, Longlong, Weng, Kai, Li, Lujie, Xie, Jianwei, Li, Ping. 2024. BATF2 inhibits the stem cell-like properties and chemoresistance of gastric cancer cells through PTEN/AKT/β-catenin pathway. In Theranostics, 14, 7007-7022. doi:10.7150/thno.98389. https://pubmed.ncbi.nlm.nih.gov/39629124/
2. Zhang, Xin, Liu, Yi, Dai, Lei, Zheng, Lei, Deng, Hongxin. 2021. BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells. In Oncogene, 40, 1516-1530. doi:10.1038/s41388-020-01627-y. https://pubmed.ncbi.nlm.nih.gov/33452462/
3. van der Geest, Rick, Peñaloza, Hernán F, Xiong, Zeyu, Bain, William G, Lee, Janet S. 2023. BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection. In American journal of physiology. Lung cellular and molecular physiology, 325, L604-L616. doi:10.1152/ajplung.00441.2022. https://pubmed.ncbi.nlm.nih.gov/37724373/
4. Le, Duy T, Florez, Marcus A, Kus, Pawel, Malovannaya, Anna, King, Katherine Y. 2023. BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection. In iScience, 26, 106059. doi:10.1016/j.isci.2023.106059. https://pubmed.ncbi.nlm.nih.gov/36824275/
5. Zhou, Jie, Lei, Zengjie, Chen, Jianfang, Li, Jianjun, Liang, Houjie. . Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1. In Clinical and translational medicine, 13, e1260. doi:10.1002/ctm2.1260. https://pubmed.ncbi.nlm.nih.gov/37151195/
6. Liu, Junwei, Li, Jie, Tuo, Zhan, Hu, Weidong, Liu, Jun. 2023. BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer. In The Journal of biological chemistry, 299, 105302. doi:10.1016/j.jbc.2023.105302. https://pubmed.ncbi.nlm.nih.gov/37777155/
7. Wen, Haojie, Tang, Jinyong, Cui, Yi, Hou, Minhua, Zhou, Juan. 2022. m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA. In Cell cycle (Georgetown, Tex.), 22, 100-116. doi:10.1080/15384101.2022.2109897. https://pubmed.ncbi.nlm.nih.gov/35949109/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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