C57BL/6JCya-Tektl1em1/Cya
Common Name
Tektl1-KO
Product ID
S-KO-20259
Backgroud
C57BL/6JCya
Strain ID
KOCMP-70976-Tektl1-B6J-VB
When using this mouse strain in a publication, please cite “Tektl1-KO Mouse (Catalog S-KO-20259) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tektl1-KO
Strain ID
KOCMP-70976-Tektl1-B6J-VB
Gene Name
Product ID
S-KO-20259
Gene Alias
4931413A09Rik, Ccdc105
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000105383
NCBI RefSeq
NM_027630
Target Region
Exon 2~3
Size of Effective Region
~2.0 kb
Overview of Gene Research
Tektl1 is one of the genes enriched in male reproductive tissues. However, its exact function, associated pathways, and overall biological importance are yet to be fully characterized. Genetic models, such as gene-knockout mice, can be valuable tools for studying its function [1].
In a study using the CRISPR/Cas9 system to generate gene-deficient mice, Tektl1-deficient mice were created. Surprisingly, these mice exhibited normal fertility in natural breeding experiments, indicating that Tektl1 is not essential for male fertility [1].
In conclusion, through the model-based research of Tektl1-deficient mice, it has been revealed that Tektl1 is dispensable for male fertility. This finding contributes to a more efficient allocation of research resources in the exploration of male reproductive biology by preventing unnecessary duplication of efforts to generate knockout mice for genes without an apparent male-fertility-related phenotype [1].
References：
1. Nguyen, Tuyen Thi Thanh, Tokuhiro, Keizo, Shimada, Keisuke, Kiyozumi, Daiji, Ikawa, Masahito. 2024. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. In Frontiers in cell and developmental biology, 12, 1411162. doi:10.3389/fcell.2024.1411162. https://pubmed.ncbi.nlm.nih.gov/38835510/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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