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C57BL/6JCya-Sgpp1em1/Cya
Common Name:
Sgpp1-KO
Product ID:
S-KO-20303
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Sgpp1-KO
Strain ID
KOCMP-81535-Sgpp1-B6J-VA
Gene Name
Sgpp1
Product ID
S-KO-20303
Gene Alias
SPP; SPP1; Spph1
Background
C57BL/6JCya
NCBI ID
81535
Modification
Conventional knockout
Chromosome
12
Phenotype
MGI:2135760
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sgpp1em1/Cya mice (Catalog S-KO-20303) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021450
NCBI RefSeq
NM_030750
Target Region
Exon 1
Size of Effective Region
~4.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Sgpp1, or sphingosine-1-phosphate phosphatase 1, is an enzyme that dephosphorylates sphingosine-1-phosphate (S1P) into sphingosine, thus regulating the balance of sphingosine-S1P. It is involved in the sphingolipid metabolism pathway, which is crucial for many cellular functions such as cell survival, proliferation, and apoptosis [5].

In multiple myeloma, GFI1-dependent repression of SGPP1 increases S1P levels, protecting c-Myc protein stability and enhancing cell survival, regardless of p53 status [1]. In colorectal cancer, sevoflurane inhibits cell progression through the circ_0000423/miR-525-5p/SGPP1 axis, and miR-656-3p inhibits cell migration, invasion, and chemo-resistance by targeting SGPP1 [2,4]. In gastric cancer, knockdown of SGPP1 promotes cell invasion and migration, and its expression is an independent prognostic factor [5]. In pancreatic beta-cells, overexpression of SGPP1 prevents lipotoxicity-mediated caspase-3 activation via enhanced lipid storage and oxidative stress prevention [3].

In conclusion, Sgpp1 plays a vital role in sphingolipid metabolism, influencing various biological processes. Through gene-based research models, its significance in diseases like multiple myeloma, colorectal cancer, gastric cancer, and pancreatic beta-cell lipotoxicity has been revealed. These findings provide insights into potential therapeutic targets related to Sgpp1-mediated pathways in these disease areas.

References:
1. Petrusca, Daniela N, Mulcrone, Patrick L, Macar, David A, Galson, Deborah L, Roodman, G David. 2022. GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival. In Cancers, 14, . doi:10.3390/cancers14030772. https://pubmed.ncbi.nlm.nih.gov/35159039/
2. Kang, Xiaofang, Li, Xiaocong, Li, Yanli. 2022. Sevoflurane Suppresses the Proliferation, Migration and Invasion of Colorectal Cancer Through Regulating Circ_0000423/miR-525-5p/SGPP1 Network. In Cellular and molecular bioengineering, 15, 219-230. doi:10.1007/s12195-021-00717-5. https://pubmed.ncbi.nlm.nih.gov/35401845/
3. Tang, Yadi, Majewska, Mariola, Leß, Britta, van Echten-Deckert, Gerhild, Gurgul-Convey, Ewa. 2024. The fate of intracellular S1P regulates lipid droplet turnover and lipotoxicity in pancreatic beta-cells. In Journal of lipid research, 65, 100587. doi:10.1016/j.jlr.2024.100587. https://pubmed.ncbi.nlm.nih.gov/38950680/
4. Zhang, Baoming, Gao, Shanting, Bao, Zengtao, Tian, Qingshui, Tang, Qiang. . MicroRNA-656-3p inhibits colorectal cancer cell migration, invasion, and chemo-resistance by targeting sphingosine-1-phosphate phosphatase 1. In Bioengineered, 13, 3810-3826. doi:10.1080/21655979.2022.2031420. https://pubmed.ncbi.nlm.nih.gov/35081855/
5. Gao, Xiang Y, Li, Lin, Wang, Xiao H, Jiang, Wen G, Ji, Jia F. 2015. Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications. In Oncology reports, 34, 1977-87. doi:10.3892/or.2015.4162. https://pubmed.ncbi.nlm.nih.gov/26239167/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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