C57BL/6JCya-Tex9em1/Cya
Common Name:
Tex9-KO
Product ID:
S-KO-20329
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tex9-KO
Strain ID
KOCMP-21778-Tex9-B6J-VB
Gene Name
Product ID
S-KO-20329
Gene Alias
Gm19407; tsec-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tex9em1/Cya mice (Catalog S-KO-20329) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000184125
NCBI RefSeq
NM_009359
Target Region
Exon 8~9
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Tex9, short for Testis-expressed protein 9, is a gene with its function still being explored. It has been associated with ciliogenesis/flagellum formation in germ cells, indicating its importance in male reproductive biology [4]. Also, it may be related to ciliary functions as its cilia/basal body localization has been experimentally confirmed [2].
In esophageal squamous cell carcinoma (ESCC), Tex9 and eIF3b functionally synergize to promote cell proliferation and migration, while inhibiting apoptosis. They achieve this through the activation of the AKT signaling pathway, suggesting a novel mechanism for ESCC progression [1]. In an in vivo functional genomics screening in mice, Tex9 was identified as one of the genes that regulate in vivo sensitivity to immune attack in a syngeneic triple-negative breast cancer (TNBC) model, demonstrating its role in anti-tumor immunity [3].
In conclusion, Tex9 is involved in important biological processes such as male reproduction-related ciliogenesis and in disease-related contexts like ESCC progression and anti-tumor immunity. The findings from in vivo studies in mice and cell-based experiments in ESCC have provided insights into its functions, which may help in understanding these biological processes and developing relevant therapeutic strategies.
References:
1. Xu, Fengkai, Zhang, Shu, Liu, Zhonghe, Ge, Di, Lu, Chunlai. 2019. TEX9 and eIF3b functionally synergize to promote the progression of esophageal squamous cell carcinoma. In BMC cancer, 19, 875. doi:10.1186/s12885-019-6071-9. https://pubmed.ncbi.nlm.nih.gov/31481019/
2. Nevers, Yannis, Prasad, Megana K, Poidevin, Laetitia, Poch, Olivier, Lecompte, Odile. . Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling. In Molecular biology and evolution, 34, 2016-2034. doi:10.1093/molbev/msx146. https://pubmed.ncbi.nlm.nih.gov/28460059/
3. Shuptrine, Casey W, Ajina, Reham, Fertig, Elana J, Hartman, Zachary C, Weiner, Louis M. 2017. An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. In Cancer immunology, immunotherapy : CII, 66, 1529-1544. doi:10.1007/s00262-017-2047-2. https://pubmed.ncbi.nlm.nih.gov/28770278/
4. Vandenbrouck, Yves, Pineau, Charles, Lane, Lydie. 2020. The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology. In Journal of proteome research, 19, 4782-4794. doi:10.1021/acs.jproteome.0c00516. https://pubmed.ncbi.nlm.nih.gov/33064489/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen