C57BL/6JCya-Fgf7em1/Cya
Common Name
Fgf7-KO
Product ID
S-KO-20416
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14178-Fgf7-B6J-VA
Status
When using this mouse strain in a publication, please cite “Fgf7-KO Mouse (Catalog S-KO-20416) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fgf7-KO
Strain ID
KOCMP-14178-Fgf7-B6J-VA
Gene Name
Product ID
S-KO-20416
Gene Alias
Kgf, Fgf5b
Background
C57BL/6JCya
Gene Full Name
fibroblast growth factor 7
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 2 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000064794
NCBI Transcript ID
NM_008008
Target Region
Exon 3
Size of Effective Region
~0.8 kb
Overview of Gene Research
Fgf7, also known as keratinocyte growth factor, is a member of the fibroblast growth factor (FGF) family. It is secreted exclusively by the mesenchyme and specifically activates the "b" isoforms of FGFR1 (FGFR1b) and FGFR2 (FGFR2b) in the overlying epithelium, contributing to the development of essentially all organs, glands, and limbs [2].
Single-cell RNA-seq analysis revealed that Fgf7 mediates a novel interaction between muscle fibro-adipogenic progenitors (FAPs) and satellite cells. Exogenous FGF7 enhances satellite cell proliferation, benefits muscle regeneration, and counteracts age-related myopathy [1]. FGF7 can also enhance the expression of ACE2 in human islet organoids, facilitating SARS-CoV-2 infection and impairing insulin secretion [3]. In osteoblasts, FGF7 increases the expression of E11, promotes dendrites elongation and functional gap junctions formation [4]. In fusion-positive rhabdomyosarcomas, FGF7-FGFR2 autocrine signaling increases growth and chemoresistance [5]. FGF7 peptide (FGF7p) can mitigate bladder urothelial injury from cyclophosphamide [6]. Cancer-associated fibroblast-secreted FGF7 promotes ovarian cancer progression [7]. Pea sprout extract can enhance the expression of FGF7, potentially promoting hair growth [8]. In non-small lung cancer, CAFs with high FGF7 expression can robustly or moderately protect cancers [9]. FGF7 shows opposite effects in osteoporosis and osteoarthritis, protecting against osteoporosis but exacerbating osteoarthritis [10].
In conclusion, Fgf7 plays crucial roles in multiple biological processes and disease conditions. Its functions range from muscle regeneration, islet cell-virus interaction, bone-related cell regulation, to cancer progression and hair growth. The study of Fgf7 in different research models helps to understand its diverse biological functions and provides potential therapeutic targets for related diseases.
References：
1. Ma, Lu, Meng, Yingying, An, Yalong, Yang, Gongshe, Li, Xiao. 2024. Single-cell RNA-seq reveals novel interaction between muscle satellite cells and fibro-adipogenic progenitors mediated with FGF7 signalling. In Journal of cachexia, sarcopenia and muscle, 15, 1388-1403. doi:10.1002/jcsm.13484. https://pubmed.ncbi.nlm.nih.gov/38751367/
2. Zinkle, Allen, Mohammadi, Moosa. 2019. Structural Biology of the FGF7 Subfamily. In Frontiers in genetics, 10, 102. doi:10.3389/fgene.2019.00102. https://pubmed.ncbi.nlm.nih.gov/30809251/
3. Meng, Hao, Liao, Zhiying, Ji, Yanting, Xu, Tao, Liu, Huisheng. 2024. FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection. In Signal transduction and targeted therapy, 9, 104. doi:10.1038/s41392-024-01790-8. https://pubmed.ncbi.nlm.nih.gov/38654010/
4. Liu, Xiaoyu, Bai, Mingru, Sun, Yimin, Xie, Jing, Ye, Ling. 2021. FGF7-induced E11 facilitates cell-cell communication through connexin43. In International journal of biological sciences, 17, 3862-3874. doi:10.7150/ijbs.65240. https://pubmed.ncbi.nlm.nih.gov/34671204/
5. Milton, Christopher I, Selfe, Joanna, Aladowicz, Ewa, Kirkin, Vladimir, Shipley, Janet M. 2021. FGF7-FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas. In Molecular oncology, 16, 1272-1289. doi:10.1002/1878-0261.13145. https://pubmed.ncbi.nlm.nih.gov/34850536/
6. Narla, Sridhar Tatarao, Rice, Lori, Ostrov, David, Duara, Joanne Lindsey, Bates, Carlton Matthew. . FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide. In Physiological reports, 10, e15241. doi:10.14814/phy2.15241. https://pubmed.ncbi.nlm.nih.gov/35388988/
7. Feng, Songwei, Ding, Bo, Dai, Zhu, Xiao, Zhongdang, Shen, Yang. 2024. Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter. In Journal of translational medicine, 22, 280. doi:10.1186/s12967-024-05085-y. https://pubmed.ncbi.nlm.nih.gov/38491511/
8. Grothe, Torsten, Wandrey, Franziska, Schuerch, Cornelia. 2019. [Not Available]. In Phytotherapy research : PTR, 34, 428-431. doi:10.1002/ptr.6528. https://pubmed.ncbi.nlm.nih.gov/31680356/
9. Hu, Haichuan, Piotrowska, Zofia, Hare, Patricia J, Niederst, Matthew J, Engelman, Jeffrey A. 2021. Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. In Cancer cell, 39, 1531-1547.e10. doi:10.1016/j.ccell.2021.09.003. https://pubmed.ncbi.nlm.nih.gov/34624218/
10. Li, Liu-Cheng, Liu, Lei, Xu, Feng, Wang, Yu-Zhen, Mao, Kai-Li. . Unraveling the role of FGF7 in osteoarthritis and osteoporosis: Therapeutic implications and challenges. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 39, e70479. doi:10.1096/fj.202500226R. https://pubmed.ncbi.nlm.nih.gov/40134324/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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