C57BL/6JCya-Etfbkmtem1/Cya
Common Name:
Etfbkmt-KO
Product ID:
S-KO-20427
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Etfbkmt-KO
Strain ID
KOCMP-320204-Etfbkmt-B6J-VB
Gene Name
Product ID
S-KO-20427
Gene Alias
4833442J19Rik; ETFB-KMT; Mettl20
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Etfbkmtem1/Cya mice (Catalog S-KO-20427) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000179873
NCBI RefSeq
NM_001252096
Target Region
Exon 3
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Etfbkmt, also known as ETFβ-KMT, is a gene encoding a protein that may be involved in important biological functions. It has been associated with the "generation of precursor metabolites and energy" process, and may play a role in the oxidoreductase activity pathway [4]. It is thought to be a candidate gene for neurodevelopmental disorders and is also associated with reproductive traits in cows [2,3,4].
In a study on hepatic fibrosis, transcriptomic analysis of MED1-deficient mice treated with carbon tetrachloride showed that Etfbkmt was among the oxidoreductase activity-related genes that were robustly reduced. This indicates that in the context of this model, the change in Etfbkmt expression may be related to the inhibition of hepatic fibrogenesis through the reduction of reactive oxygen species (ROS) and the blocking of the TGF-β/Smad2/3 pathway [1].
In conclusion, Etfbkmt is potentially involved in multiple biological processes, including energy-related metabolism, neurodevelopment, and reproduction. The gene knockout-like situation in the MED1-deficient mouse model in the context of hepatic fibrosis research reveals its possible role in regulating fibrogenesis through pathways related to ROS and TGF-β signaling. This suggests that studying Etfbkmt in gene-knockout models can provide insights into its functions in specific disease-related processes such as liver fibrosis [1,2,3,4].
References:
1. Gao, Jie, Bao, Miaoye, Xing, Yuanming, Liu, Enqi, Bai, Liang. 2023. Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice. In American journal of physiology. Gastrointestinal and liver physiology, 325, G418-G428. doi:10.1152/ajpgi.00076.2023. https://pubmed.ncbi.nlm.nih.gov/37668531/
2. Ben-Mahmoud, Afif, Kishikawa, Shotaro, Gupta, Vijay, Layman, Lawrence C, Kim, Hyung-Goo. 2023. A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome. In Scientific reports, 13, 12984. doi:10.1038/s41598-023-40037-4. https://pubmed.ncbi.nlm.nih.gov/37563198/
3. Ben-Mahmoud, Afif, Kishikawa, Shotaro, Gupta, Vijay, Layman, Lawrence C, Kim, Hyung-Goo. 2023. A microdeletion del(12)(p11.21p11.23) with a cryptic unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome. In Research square, , . doi:10.21203/rs.3.rs-2572736/v1. https://pubmed.ncbi.nlm.nih.gov/37034680/
4. Hosseinzadeh, Sevda, Rafat, Seyed Abbas, Fang, Lingzhao. 2025. Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows. In Scientific reports, 15, 1932. doi:10.1038/s41598-024-82448-x. https://pubmed.ncbi.nlm.nih.gov/39809816/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen