Colleagues - Save up to 25%
Collaborate with colleagues to order multiple animal models together and everyone can enjoy higher discounts - save up to 25% when performing 4 or more projects! Start your progress now by registering below as either a Referrer (to begin inviting colleagues) or Invitee (those who received a colleague’s invite to join a group discount). Our experts will follow up to provide your complimentary project strategy details and quote.
If your research colleagues have projects involving custom mouse or rat generation or require the use of KO/cKO mouse models, place an order now and enjoy great discounts ranging from 10% - 25%.
| Custom Mouse and Rat Model Services | ||||||
|---|---|---|---|---|---|---|
| Model Generation Services | Species | 1 Project | ≥2 Projects | ≥3 Projects | ≥4 Projects | |
| HUGO-GT™ Next-Generation Humanized Models | Mouse | 10% off | 15% off | 20% off | 25% off | |
| ES Cell-Mediated Gene Modification | TurboKnockout | Mouse only | ||||
| CRISPR- based Gene Editing | Knockout (KO) | Mouse or Rat | ||||
| KI (any locus) | ||||||
| KI (ROSA26) | ||||||
| Point mutation | ||||||
| cKO | ||||||
| Knockout Catalog Models | Knockout (KO) | Mouse only | ||||
| Conditional KO (cKO) | ||||||
- Academic end clients in Europe, North America, and South America.
- Promotional pricing is only available for new projects under the “Applicable Services” described below. This offer may not be combined with any other offer or discount.
- You will be enrolled in the Referral program only when filling in the Request Forms as required for either the Referrer or Invitee. Enrollees must use a valid business and/or academic email account (no personal accounts, e.g. @gmail.com).
- Each Invitee referral will be considered applicable to the total group discount awarded only once the project has been quoted and initiated. All invitees must be confirmed within 30 days of the first project initiation to finalize the group discount rate for all related project payments.
- Ask us about higher discount opportunities for ordering additional projects and/or combining with our CRO services, such as mouse colony management solutions and breeding.
- Cyagen reserves the right of final explanation for details governing this Referral Program and administration of discount/savings awards. Please contact our customer service team (animal-service@cyagen.com) if you have further questions.
I would like to recommend that you tryout Cyagen’s research products & services! You can participate in Cyagen’s best offer using this link:
Through Cyagen’s referral program, both you and I will receive up to 25% off animal models for our research! Join me in ordering animal models together and everyone can enjoy higher discounts for research-ready rodent models with a guaranteed genotype.
Search by your gene of interest on our Knockout Catalog below to discover your next KO mouse model. Submit an inquiry and our team will be in touch within 48 hours to provide you with a project quote.
| Custom Mouse & Rat Model Generation | ||
|---|---|---|
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Knockouts (KO)
Constitutive knockouts can be quickly generated utilizing TurboKnockout®
embryonic stem cell (ESC) based technology providing ESC based models at timelines comparable to
CRISPR based models. CRISPR is also available, with AI-based bioinformatic analysis driving
identification of the optimal region to target.
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Conditional Knockouts and Knock-ins (cKO/cKI)
Conditional knockouts and knock-ins can also be quickly generated using
TurboKnockout®. With a germline guarantee and self-deleting selection cassette, TurboKnockout®
accelerates traditional ESC based model generation.
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Point Mutation Knock-ins
Point mutations can be quickly generated via CRISPR or Cyagen’s accelerated
ESC based method, TurboKnockout®, enabling more complex point mutations and/or genetic modifications.
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Large-fragment Knock-ins (LFKI)
Rosa26 and other safe harbor loci can be targeted for large fragment knock-ins (LFKI) using a variety of methodologies to ensure your studies are not limited by technology or capability. With the ability to perform LFKI at any locus, the only limit to your studies is your ingenuity.
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Humanization
Humanized models have been widely used in studies of human gene function,
immuno-oncology therapeutics, infectious disease pathology, and preclinical drug evaluation in the
field of biomedicine. Our TurboKnockout® technology enables more efficient and stable gene integration
for the development of humanized mouse models, including our HUGO-GT™ Next-Generation Humanized
Models.
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Transgenics
With the capability to generate both traditional and PiggyBac-based
transgenics, we can provide your research with cost-effective transgenic models with the ability to
avoid gene silencing with single- copy-per-integration-site, and no loss of transgene sequence when
using PiggyBac.
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Multiple Donor Strains Available
● Mouse: C57BL/6, FVB, BALB/c
● Rat: Sprague-Dawley (SD), Wistar, F344, Long evans, Brown Norway |
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- No patent risk: Technology of choice for drug development projects
- Success rate: 100% guaranteed germline transmission (GLT)
- Turnaround time: Founders as fast as 6-8 months
- Large fragment knockin size: Knockin (KI) fragment size up to 300 kb
- Limitless loxP: No size limitations for your floxed region
- 100% Money-Back Guarantee on TurboKnockout® projects
Our HUGO-GT™ Next-Generation Humanized Models employ our proprietary TurboKnockout-Pro technology to perform in-situ replacement of the targeted mouse endogenous gene, creating full-length genomic sequence humanized mouse models with a broader range of intervention targets. Cyagen's HUGO-GT™ model steps in to replace existing humanized models, catering to the needs of preclinical research and pharmaceutical companies.
- Efficient Drug Screening: The humanized region of the HUGO-GT™ model mirrors the pathogenic genes in humans and encompasses most drug targets.
- Gene Therapy Research Platform: Especially beneficial for gene therapy drugs requiring stringent gene sequence integrity, such as ASO, CRISPR, and siRNA.
- Full-length Coverage of Pathogenic Genes: Large-scale genomic segment replacement allows for complete coverage of disease hotspot mutation regions, including exons, introns, and both UTR regions.
- Tailored Customization: Custom site-specific targeting of large gene segments up to 350 Kb.
- Rapid Disease Model Development: We can modify existing HUGO-GT™ wild-type (WT) humanized ES cells to develop mutation-specific models of disease.
generation project consultation, strategy, and quote.
