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Cyagen Exclusive White Paper :
Animal Models of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) and Steatohepatitis (MASH)
Cyagen Exclusive White Paper

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the steatotic liver disease associated with metabolic syndrome that is the most common chronic liver disease worldwide. It affects more than 30% of the global population and the leading cause of liver-related morbidity and mortality. MASLD is a hepatopathy syndrome affecting both adults and children, characterized by a range of liver conditions including simple fatty liver, steatohepatitis, fatty liver fibrosis, and cirrhosis. Furthermore, the presence of obesity-related metabolic syndromes—including obesity, dyslipidemia, hypertension, and glucose intolerance—increases the likelihood that a patient has metabolic dysfunction-associated steatohepatitis (MASH) rather than simple steatosis. MASH is the advanced stage of MASLD. MASLD can advance from simple fatty liver into metabolic dysfunction-associated steatohepatitis (MASH)-related inflammation and liver fibrosis, and even lead to end-stage liver diseases such as liver cirrhosis, hepatocellular carcinoma (HCC), or liver failure.

Download the white paper to explore the metabolic dysfunction-associated steatotic liver disease (MASLD) >>


Outline of Contents:
 Introduction of MASLD and MASH
 Types of Animal Models Used to Research MASLD and MASH
 Diet-Induced Models
 Chemically Induced Models
 Genetically Modified Models
 Composite (Combined) Models
 The Most Commonly Used Composite Models
About Cyagen
About Cyagen

Over the past 18 years since its founding, Cyagen has become a leading provider of custom mouse and rat models. We have delivered over 50,000 models to researchers worldwide and received over 9,000 peer-reviewed citations. Our AAALAC accredited facility can house up to 250,000 SPF animals, ensuring high-quality standards and compliance.

From strategy design to the delivery of research-ready custom models, Cyagen offers complete outsourcing for all your cell and animal model needs. We provide expertise in animal genetic modification and custom model generation in our collaborations with over 7,000 bioscience institutions across the world. Our services include creating any custom mouse or rat model with guaranteed genotype validation, phenotypic characterization, drug efficacy evaluations, and other downstream services to meet your research needs.

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