Research Trend
KO-First: A Tool for Studying Gene Function Across the Mammalian Genome
KO-First: A Tool for Studying Gene Function Across the Mammalian Genome
Since the early 2000s, large-scale knockout consortia have been established with the goal of generating a complete resource of reporter-tagged null mutations in C57BL/6 mouse ES cells. Herein, we provide a brief introduction to the ‘knockout-first’ (KO-first)
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Breaking News
CRISPR-Cas9: How the Patent Dispute has Transformed Science Innovation
CRISPR-Cas9: How the Patent Dispute has Transformed Science Innovation
As CRISPR-based innovations begin to move into clinical testing and the dispute over core patents continues worldwide, CRISPR-Cas9 gene editing has been under increased scrutiny in both commercial and academic sectors.
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Research Trend
RPS23RG1-mediated Stabilization of Synaptic Function Rescues AD-Associated Cognitive Deficits
RPS23RG1-mediated Stabilization of Synaptic Function Rescues AD-Associated Cognitive Deficits
Synaptic impairment is known to be a prerequisite to the cognitive deficiencies exhibited in Alzheimer's Disease (AD), so investigating the mechanisms which
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Latest Discovery
Advancing the Study of Cardiac Chamber Specification During Development & Pathological Remodeling
Advancing the Study of Cardiac Chamber Specification During Development & Pathological Remodeling
Nppa (natriuretic peptide A) is a cardiac hormone that dynamically changes its spatiotemporal expression during heart development.
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Research Trend
The State of Genetically Modified Mouse Models in 2019 – Advances in Human Disease Research
The State of Genetically Modified Mouse Models in 2019 – Advances in Human Disease Research
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas.
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Research Trend
Improving Cancer Models with Humanized Mice
Improving Cancer Models with Humanized Mice
Mouse models have been instrumental in elucidating the pathobiology of cancer formation and inhibition, including that of Colorectal Cancers (CRC) and Prostate Cancers.
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Newsletter
Custom Animal Models for Improving Human Disease Research
Custom Animal Models for Improving Human Disease Research
If your lab is working on research projects that utilize mouse/rat models, off-the-shelf models often come with limitations that may be addressed through genomic modifications to improve homology.
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Research Trend
Application of Toll-Like Receptors (TLRs) Animal Models in Cancer and Autoimmune Disorders
Application of Toll-Like Receptors (TLRs) Animal Models in Cancer and Autoimmune Disorders
Toll-like receptors (TLRs) are a class of transmembrane proteins that play essential roles in mammalian innate immune responses against infection. In general, TLRs can recognize structurally conserved molecules, collectively referred to
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Research Trend
Custom Animal Models of Neurodegeneration for Investigation of Potential Therapeutics
Custom Animal Models of Neurodegeneration for Investigation of Potential Therapeutics
Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis, such as tau accumulation, amyloid-β deposition, and altered network oscillations. Synaptic and neuronal loss are also typical of many of neurodegenerative diseases
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Research Trend
How microRNA may be used to promote heart regeneration
How microRNA may be used to promote heart regeneration
Recent research has aimed to enhance the regeneration capacity of adult cardiomyocytes (CMs), in part by addressing their withdrawal from the cell cycle following myocardial infarction (MI). As a suggested regulator of endogenous CM proliferation
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