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Research Trends
Small Nucleic Acid Drug Evaluation Model for Spinal Muscular Atrophy Research - B6-hSMN2(SMA) Mice
Feb 29, 2024
Today, we'll be introducing a model of Spinal Muscular Atrophy (SMA) - B6-hSMN2(SMA) mice. But before delving into this mouse model, let's first introduce the basic pathology of SMA. Read More >
Research Trends
Preclinical R&D Interest Soars as the First AAV Gene Therapy for DMD Hits $200 Million in Sales
Feb 22, 2024
Jointly developed by Sarepta Therapeutics and Roche, ELEVIDYS is an adeno-associated virus vector-based gene therapy indicated for the treatment of ambulatory pediatric patients aged 4 - 5 years with Duchenne muscular dystrophy (DMD) with a confirmed mutation in the DMD gene. The United States Food and Drug Administration authorized accelerated approval for this indication based on expression of ELEVIDYS micro-dystrophin in skeletal muscle observed in patients treated with ELEVIDYS in June 2023. Read More >
Research Trends
Obesity Research Mice Introduction (Part 2): Non-LEP/LEPR Genetic Models
Feb 18, 2024
In our previous article, we provided an “Introduction to Murine Models of Obesity (Part 1): LEP/LEPR Classic Pathway Model”. In this edition, we will delve into non-LEP/LEPR genetic mouse models for obesity research. Read More >
Research Trends
Introduction to Murine Models of Obesity (Part 1): LEP/LEPR Classic Pathway Model
Jan 31, 2024
To effectively conduct research on obesity and its prevention and treatment, it is crucial to comprehend the mechanisms underlying obesity. Leveraging mouse models of obesity-related diseases is essential for gaining meaningful insights into the prevention and treatment of obesity and its complications. Read More >
Research Trends
Challenges of Performing Orthotopic Colorectal Cancer Modeling: Evaluating the Effectiveness of Modeling Site Exploration
Jan 26, 2024
Colorectal cancer is a common malignant tumor that occurs in the colon, predominantly in the junction between the rectum and sigmoid colon. It ranks as the third most common gastrointestinal tumor with the highest incidence in the age group of 40 to 50 years, with a male-to-female ratio of 2-3:1. Read More >
Breaking News
Cyagen Congratulates Our Partner INNOVEC on Receiving FDA Pediatric Rare Disease Designation (RPDD) for IVB102 Injection
Jan 23, 2024
The United States Food and Drug Administration (FDA) granted Beijing InnoVec Biotherapeutics’ InnoVex IVB102 injection the Rare Pediatric Disease Designation (RPDD) on January 10, 2024. Innovec is now one step closer to being eligible for the Rare Pediatric Disease Priority Review Voucher (PRV) for the treatment of rare pediatric diseases with the InnoVex IVB102 injection in the United States. Read More >
Research Trends
Circumventing Difficulties in Dynamic Monitoring of Orthotopic Tumor Transplantation Models with In Vivo Bioluminescent Imaging
Jan 12, 2024
Compared to the traditional method of euthanizing animals in batches to obtain experimental data, real-time bioluminescence imaging (BLI) technology allows for qualitative and quantitative observations at the cellular and molecular levels of a living organism. Read More >
Ten Deadly Sins of Rare Diseases
Unraveling Rare Diseases: Researching Hotspot Pathogenic Mutations in Humanized Models
Dec 29, 2023
Welcome to the 'Ten Deadly Sins of Rare Diseases' column, where we decode the pathogenic mechanisms of rare diseases, industry research progress (e.g. gene therapy), and innovative pre-clinical strategies to drive translational research results (such as model construction and drug screening, etc.). Read More >
Research Trends
Breaking Stereotypes: Diabetes Research, GLP-1, and the Roadmap for Preclinical Studies
Dec 18, 2023
On November 14th, World Diabetes Day serves as a global call to action to confront the complexities of diabetes, a condition that often grapples with various stereotypes and misconceptions. It's a common misbelief that only overweight individuals are at risk of diabetes or that young people need not be concerned about it. Read More >
Research Trends
Age-Related Health Challenges in Lab Rats: A Comprehensive Examination
Dec 11, 2023
In this issue, we will be discussing another factor that is often overlooked but can significantly impact rat health — age. Get ready to learn more about the impacts of rodent age on health! Read More >