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Video
How Knockout Mice are Developed with Traditional Gene Targeting
Jan 15, 2021
From the creation of the first knockout (KO) mouse, scientists have come extremely far. CRISPR technologies have quickly become a leading method used by genetic knockout scientists today, in part due to the method’s short turnaround. Read More >
Latest Discovery
Research Trend
Novel Mouse Model for Researching RAB7A and NF-kB Activation
Jan 12, 2021
A recent study has suggested that that NF-kB activation is boosted by colocalization of engaged immune receptors (i.e., CD40) with RAB7 small GTPase on mature endosomes in mouse B cells. This research was enabled by using a conditional (floxed) gene knockin mouse model - Cd19+/creRosa26+/fl-STOP-fl-Rab7 (Rab7 B-Tg) – which is designed to express untagged RAB7 in CD19+ B cells. Read More >
Newsletter
[Gene of the Week] Alzheimer's Disease and Genes - APOE (Apolipoprotein E)
Dec 22, 2020
In our fourth Gene of the Week article, we continue covering genes related to the development of Alzheimer's disease (AD). Several mutations in APOE (Apolipoprotein E) have been identified to not only increase the risk of developing AD, but other neurological and cardiovascular diseases. Read More >
Newsletter
Announcing the Cyagen YouTube Channel
Dec 17, 2020
Have you ever searched on YouTube for a biology concept that you didn’t fully understand, only to come across basic whiteboard tutorials or grainy homemade videos with people who can’t clearly explain the concepts? Given Cyagen’s position as a leading provider of custom genetically modified mouse and rat models worldwide, we felt drawn to answer the call for quality explainer videos related to the field of gene engineering. Read More >
Newsletter
[Gene of the Week] Alzheimer's Disease and Genes - TREM2
Dec 14, 2020
Specific mutations in TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) have been confirmed to increase the risk of developing late-onset AD. Here, we review the current data detailing the function of TREM2 and its role in Alzheimer's disease (AD). Read More >
Newsletter
Large Fragment Knock-In Mouse Models Using Recombinase-Mediated Cassette Exchange
Dec 10, 2020
Since the beginnings of gene editing research, the ability to accurately modify large genomic regions has remained a primary driver of innovation in the field. Although gene editing technologies have been continuously refined, the size of the modifiable region is still constrained depending on the methods used. Read More >
Newsletter
New Cyagen Custom Mouse Model Publication Alert – December 2020
Dec 01, 2020
Herein, we have selected several high-impact factor (IF) publications from May through October 2020, which use custom genetically modified mouse models developed by Cyagen. These citations cover a broad range of research fields, including immunology, inflammation, cardiology, oncology, metabolomics, and epigenetics. Read More >
Research Trend
Newsletter
White Paper
Applications of the Mouse Model in Translational Medical Research
Nov 16, 2020
The mouse model has become an irreplaceable model organism for biomedical research, which includes studying gene function and genetic factors of pathogenesis, establishing humanized disease models, and evaluating the safety and effectiveness of drugs under development. Read More >
Weekly Gene
Research Trend
[Gene of the Week] Alzheimer's Disease and Genes - PSEN1 (Presenilin 1)
Nov 12, 2020
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. In this review, we discuss the current research and understanding of the PSEN1 gene and its mutation which causes familial Alzheimer's disease (FAD). Read More >
Newsletter
Research Trend
Genes of Fear – Halloween Special
Oct 29, 2020
Happy Halloween from Cyagen! To celebrate and educate, our team has put together brief synopses of several genes related to fear: STMN1, P4H-TM, ANXA1, FPR1, DAGLA, and TAAR1. Read on to learn about each gene’s functions, research progress, and opportunities for discovery. Read More >