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Research Trends
How to overcome the challenge of model selection in DMD gene therapy?
May 30, 2023
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder caused by mutations in the DMD gene, resulting in abnormal function of the dystrophin protein. Read More >
Research Trends
Advancements in CAR-T Cell Therapy: Maximizing Therapeutic Efficacy while Minimizing Toxicity
May 26, 2023
In the last chapter (click to review), we mentioned that chimeric antigen receptor (CAR)-T cell therapy has been extremely successful in treating relapsed/refractory B-cell malignancies expressing CD19, however, there are still many toxicities in clinical applications, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Read More >
Research Trends
What are the obstacles hindering the development of CAR-T therapy?
May 18, 2023
After years of development, chimeric antigen receptor (CAR) T cell therapy has become a revolutionary method for cancer treatment. Among them, CD19 targeting drugs have achieved unprecedented success in the treatment of B-cell malignancies and were approved by the US FDA in 2017. Read More >
Research Trends
Mastering CAR Structure and Design for Enhanced Anti-Tumor Response with CAR-T Cell Therapy
May 12, 2023
Chimeric antigen receptors (CARs) are engineered synthetic receptors that redirect lymphocytes, most commonly T-cells, to recognize and eliminate cells expressing specific target antigens. CAR binding to target antigens on the cell surface is independent of MHC receptors, resulting in vigorous T-cell activation and potent anti-tumor responses. Read More >
Cyagen CEO Lance Han - Pushing Therapeutic Advances Through Modelling
Apr 24, 2023
Cyagen Biosciences CEO Lance Han was recently featured in an interview with CEO Insights Asia Magazine. In the interview, Han discussed his vision for the future of biotech and gene editing and shared insights on how Cyagen is pioneering innovation in cell and gene therapy research through data-driven solutions. Additionally, Han was recognized by the magazine as one of the TOP 10 TSINGHUA UNIVERSITY ALUMNI LEADERS - 2023, a prestigious accolade that showcases his exceptional leadership skills and contributions to the biotech industry. Read More >
Research Trends
Frequently Asked Questions (FAQ) on Mouse Models for Ophthalmic Diseases
Apr 21, 2023
Due to the limited efficacy of traditional treatments, ophthalmic diseases have quickly become a breakthrough point for gene therapy, but many questions about mouse models for preclinical ophthalmology research remain. Read More >
Research Trends
Revolutionizing Neovascular Ophthalmology Research: Cyagen's Phenotypically Stable Humanized VEGF Mice
Apr 13, 2023
As a popular target for treating diseases like macular degeneration and tumors, vascular endothelial growth factor (VEGF) has already had several drugs approved for clinical use and has made significant progress. In February of this year, researchers completed the first Phase I clinical trial of a recombinant anti-VEGFA and VEGFC bispecific antibody fusion protein in a for age-related macular degeneration with neovascularization. Read More >
Research Trends
Humanized VEGFA Mouse Models for Preclinical Wet AMD Ophthalmology Research
Mar 30, 2023
Recently, researchers announced that they have found a new target for inhibiting vascular endothelial growth factor (VEGF), which can improve the symptoms of ophthalmic diseases. This is achieved by affecting the release of VEGF and choroidal neovascularization through fat mass and obesity-associated protein (FTO) inhibition. Read More >
Research Trends
Applications of iPSC-based Disease Models
Feb 16, 2023
Induced pluripotent stem cells (iPSCs) provide an ideal in vitro platform for studying disease mechanisms and developing cell therapy approaches, as they can be derived from cells with a singular genetic background and tailored to replicate specific disease phenotypes. Read More >
Research Trends
What is Autism Spectrum Disorder (ASD) and what are the gene-edited mouse models for autism?
Jan 29, 2023
Autism Spectrum Disorder (ASD) refers to a broad range of complex neurodevelopmental conditions that has many theorized causative factors, but there have been many genetic mutations associated with susceptibility to autism and altered brain structure associated with ASD. Read More >