Research Trend
Using S100a9 Knockout Mice to Identify Therapeutic Targets for MI/R Injury
The human S100A9 gene encodes the S100 calcium-binding protein A9 (S100A9). In mammals, S100A8 and S100A9 proteins form a heterodimer known as calprotectin. Calprotectin is involved in the inflammatory process - it is known to be present as a soluble protein in the cytosol of neutrophil granulocytes, and is found in lower concentrations among in monocytes, macrophages, and squamous epithelial cells. Read More ›
COVID-19 Research Trend
Mouse Models for SARS - Construction Strategies and Applications
Recent news continues to show that the COVID-19 pandemic situation globally is far from being over. Across the entire world, the pneumonia-like COVID-19 caused by the novel coronavirus (SARS-CoV-2) remains a huge medical challenge. Read More ›
COVID-19 Research Trend
From Bats to Humans: How SARS-CoV-2 Jumped Across Species
Although the origin of the new coronavirus remains inconclusive, according to the analysis of existing genomic data, the scientific community has drawn preliminary conclusions that bats may be the reservoir species for the novel coronavirus (SARS-CoV-2). If this view is proved to be credible, how does the virus jump from a bat to a human? Read More ›
Newsletter
Advantages of TurboKnockout® Gene Targeting Mice
The TurboKnockout® gene targeting service by Cyagen is based on traditional embryonic stem cell (ESC)-mediated targeting techniques, which can be used for complex gene knockout projects to provide C57BL/6 or (new) BALB/c mouse models with accurate genetic modification and no off-target effects. Read More ›
Newsletter
New Cyagen Mice Publication Alert – June 2020
The following publications demonstrate the use of custom genetically modified mouse and rat models across a broad range of human disease studies, including immunological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and liver disease. Read More ›
Research Trend Latest Discovery COVID-19
Factors Contributing to the Age and Sex-Based Differences of the Novel Coronavirus - SARS-CoV-2/COVID-19
With the growing amount of coronavirus research accomplished by researchers globally, the value of the novel coronavirus (SARS-CoV-2) across many relevant research fields has been confirmed. According to big data analytics, the degree of coronavirus infection varies among different genders and different age groups. Read More ›
Research Trend Latest Discovery COVID-19
Differences in COVID-19 Severity Across Patient Populations - Age and Gender
With the growing amount of coronavirus research accomplished by researchers globally, the value of the novel coronavirus (SARS-CoV-2) across many relevant research fields has been confirmed. According to big data analytics, the degree of coronavirus infection varies among different genders and different age groups. Read More ›
Research Trend
MyD88 Signaling Pathway & IL-33 Induced Immune Response
The MYD88 gene encodes a cytosolic adapter protein, MyD88, which is involved in signaling for both the innate and adaptive immune response. The MyD88 adapter protein is essential for transducing signals in the interleukin-1 (IL-1) and toll-like receptor (TLR) pathways, which regulate activation of proinflammatory genes, and stimulating signaling molecules that activate interacting proteins called nuclear factor-kappa-B (NF-κB). Read More ›
White Paper Research Trend
Animal Models of Non-Alcoholic Fatty Liver Disease (NAFLD) and Steatohepatitis (NASH)
Non-alcoholic fatty liver disease (NAFLD), a hepatopathy syndrome affecting both adults and children, is characterized by a range of liver conditions affecting people who consume little to no alcohol, including simple fatty liver, steatohepatitis, fatty liver fibrosis, and cirrhosis. NAFLD can progress from simple fatty liver through nonalcoholic steatohepatitis (NASH) to liver fibrosis, and even lead to end-stage liver diseases, such as, liver cirrhosis, hepatocellular carcinoma (HCC), or liver failure. Read More ›
Research Trend Latest Discovery
The Latest Animal Models of Chronic Pancreatitis
While chronic pancreatitis (CP) is a relatively common disease, it remains difficult to treat. This is defined as a continuous or recurrent inflammatory pancreatic disease characterized by progressive and irreversible changes in pancreatic morphology. So far, scholars around the globe have done a lot of research on the diagnosis, treatment, and pathogenesis of the disease. Read More ›