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Research Trend
What is Huntington's Disease?
May 20, 2022
Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that has a 50% probability of being inherited by children of people living with HD. Read More >
Research Trend
Amyotrophic Laternal Sclerosis (ALS) - A Rare Disease More Common in EU&US
May 16, 2022
ALS is a motor neuron disease (MND), which is a group of neurological disorders that selectively affect motor neurons with secondary damage to muscles. The data shows that the incidence rate in Europe and the United States is higher, at 2.6/105, and the prevalence rate is almost double, at 7-9/105. Read More >
Research Trend
Racing Against Time to Treat Amyotrophic Lateral Sclerosis (ALS), A Fatal Disease
May 11, 2022
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. Read More >
Research Trend
Preclinical Pharmacological Model of CAR T-Cell Therapy
May 06, 2022
Recently, the U.S. Food and Drug Administration (FDA) has approved Carvykti, a chimeric antigen receptor (CAR) T-cell therapy product jointly developed by Legend Biotech and Johnson & Johnson, for the treatment of relapsed/refractory multiple myeloma. Read More >
Webinar Q&A
May 04, 2022
Cyagen recently hosted a live webinar covering the generation of genomically humanized mouse models for applications in preclinical research. Herein, we offer an extremely brief overview of the presentation and provide Dr. Ouyang’s personal responses to all the questions submitted during the webinar session. Read More >
Research Trend
What Do You Know about the Quality Control of rAAV Virus?
May 02, 2022
The production and preparation of rAAV is a key and difficult point in gene therapy, because the packaging system and purification method of rAAV will influence the infection efficiency and the expression efficiency of the target gene, and ultimately affect the results. Read More >
Research Trend
A Method to Study the Mechanisms of Gene Regulation
Apr 29, 2022
In December 2021, Shengde Wu’s group from the Department of Urology, Children's Hospital of Chongqing Medical University, published in a paper at Journal of Hazardous Materials, entitled Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes. Read More >
Research Trend
How AI + Minigene Aids the Research of Aberrant Alternative Splicing
Apr 26, 2022
Alternative splicing is the regulatory process of selecting different combinations of splice sites within a messenger RNA precursor (pre-mRNA) to produce variably spliced mRNAs. These multiple mRNAs can encode proteins that vary in their sequence and activity and yet all arise from a single gene. Read More >
Research Trend
Fight for Sight - Targeting Genetic Factors of Ophthalmic Diseases
Apr 22, 2022
Genes play a highly significant role in the pathogenesis of eye diseases, some of which are highly prevalent in children and adults. Read More >
Weekly Gene
SYNGAP1-Related Intellectual Disability (MRD5)
Apr 20, 2022
SYNGAP1 (Synaptic Ras GTPase Activating Protein 1) is a Protein Coding gene. The SYNGAP1 gene is located on Chromosome 6 and is responsible for producing the SynGAP protein. Read More >