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Newsletter
Human Antibody Discovery Using In-vivo Mouse Models
Jun 08, 2021
The continuous development and improvement of gene editing technology has driven the successful establishment of such a platform for mouse models expressing human antibody genes Read More >
Newsletter
Important Considerations in the Humanization of Antibodies
Jun 08, 2021
The clinical application of mouse-derived antibodies has revealed some limitations, such as causing human anti-mouse antibody (HAMA) reaction, an allergic reaction that might accelerate clearance of mouse antibodies and cause anaphylaxis. Read More >
Newsletter
How Are Therapeutic Antibodies Developed?
Jun 08, 2021
The therapeutic antibody has become a leading treatment option for cancers and other related diseases. In the past 25 years, antibody therapy has become an important treatment method for various diseases, such as cancer. Notably, from 2018 to 2019, there were about 18 new therapeutic antibody drugs approved for clinical use. Read More >
Newsletter
In Vivo Tumor Models - Cell Line-derived Tumor Xenograft (CDX) Models in Oncology Research
Jun 06, 2021
In vivo tumor models, such as cell line-derived tumor xenograft (CDX) models, play an important role in basic research of tumorigenesis and metastasis, as well as drug development and treatment. Read More >
Newsletter
What Are Immunodeficient Mice
Jun 04, 2021
Immunodeficient mice refer to the mice with defects in one or more immune components (such as T, B, NK cells) in the immune system. This type of mouse is widely used in the research of oncology (tumor growth, metastasis, anti-tumor drug screening), immunology (mechanisms of immune cell development and proliferation, pathology of immune diseases), infectious diseases (pathogenic mechanisms of viral/bacterial infectious diseases), and stem cell biology (human stem cell transplantation), and more. Read More >
Newsletter
Introduction to Tumor Models for Research
Jun 04, 2021
The establishment of tumor animal models provide a powerful tool for studying the mechanism of tumorigenesis and metastasis, even validating the efficacy of anti-tumor drugs. Rodent models have many advantages in tumor research, such as fast breeding, low cost, and versatile genetic modification. These traits make them an indispensable tool for preclinical therapeutics screening. Read More >
Newsletter
How to Avoid the Risk of Residual Protein Expression in Knockout Cell Lines
Jun 03, 2021
In this article, we review the causes of residual protein expression in knockout cell lines and provide the solution to avoid the risk of protein residue in knockout cell line models. Read More >
Weekly Gene
Pathogenic Gene of Neurodevelopmental Disorders - MECP2 Gene
May 27, 2021
Neurodevelopmental disorders are impairments of the brain and central nervous system that affect a patient’s behavior and cognition. In this article we review the MECP2 gene, a pathogenic gene of neurodevelopmental disorders, hoping to help researchers gaining proper understanding of the gene, its encoded MeCP2 protein, and related neurodevelopmental disorders. Read More >
Newsletter
Myriad of CRISPR Research Model Services
May 27, 2021
If your lab is utilizing CRISPR in animal or in-vitro modeling work, we have a wide variety of CRISPR offerings with great discounts. Read More >
Newsletter
Announcement - Introducing Cyagen Upgraded Animal Supporting Services
May 27, 2021
yagen aims to support biomedical research with our expertise. We are committed to enabling development of precise animal models to help researchers study disease mechanisms, target validation, drug screening and more. Our comprehensive services cover the entire process of animal model generation - from gene targeting strategy design and animal model development, through to breeding and animal phenotype analysis – to accelerate your scientific research progress. Read More >