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Research Trend
Transgenic Mice – Genetic Research Models Accelerating Drug Development
Apr 20, 2021
Transgenic mice are important tools for scientists to study genetic disorders and human diseases. In this article, we review the basic information on transgenic mice research, application examples, and the development process for transgenic mouse models – serving as a guide for scientists looking to gain proper understanding of transgenic mouse models. Read More >
Case Study
Research Trend
Intestinal Epithelial Cells Regulate the Differentiation of Intraepithelial Lymphocytes through the Expression of MHC II and PD-L1
Apr 20, 2021
The article entitled “Niche-specific MHC II and PD-LI regulate CD4+CD8aa+ intraepithelial lymphocyte differentiation,” published in the Journal of Experimental Medicine, first revealed the molecular mechanisms of intestinal epithelial cells (IECs) regulating T cell differentiation (IEL, intraepithelial lymphocytes). In addition, findings indicate the microbiome essential for the epithelial differentiation of MHCII, PD-L1, and IEL in the small intestine. Read More >
Weekly Gene
TARDBP: A Pathogenic Gene of Neurodegenerative Diseases
Apr 15, 2021
Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis. In the first of our Weekly Gene features covering pathogenic genes of neurodegenerative diseases, we review the functionality of TARDBP. This review, as well as the upcoming Weekly Gene articles, aim to help researchers explore potential therapeutics for neurogenerative diseases. Read More >
Weekly Gene
SNCA: A Pathogenic Gene of Neurodegenerative Diseases
Apr 15, 2021
It is well known that genes play a major role in the pathogenesis of neurodegenerative diseases. There have been major efforts in biomedical research to learn about disease-related genes, which has led to highly targeted therapeutics for several diseases that were previously untreatable. Read More >
Research Trend
Advancing Neurodegenerative Disease Research with Animal Models
Apr 08, 2021
Population aging is one of the most important social health issues in the world today and will only increase in the future. With rising life expectancy and continually low fertility rate in developed economies, it is estimated that the number of people aged 65 years or over will be 2.1 billion by 2050 - reaching as many as 3.1 billion by 2100. Read More >
Newsletter
Research Trend
Knockout Mice - An Efficient Tool for Gene Function Research
Apr 02, 2021
Knockout mice have been essential for gaining proper understanding of gene function, studying human disease mechanisms, and accelerating drug development - playing an important role in biomedical advancements across a variety of research areas. With the development of gene editing technology, knockout (KO) mice become increasingly accessible for researchers worldwide. In this article, we review the basic information on knockout mice research, application examples, and the development process for custom KO mouse models. Read More >
Newsletter
Research Trend
Rare Disease Research and Gene Therapy Resources List
Mar 29, 2021
As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of rare disease and related gene therapy research with our expertise. We are committed to enabling development of therapeutics for rare diseases by developing accessible animal models to study disease mechanisms, target validation, drug screening and more. Read More >
Weekly Gene
The Pathogenic Gene of Huntington's disease – HTT
Mar 24, 2021
Huntington's disease (HD) is a rare, progressive brain disorder that is inherited in an autosomal dominant manner - this disorder is caused by a defective huntingtin (HTT) protein that changes the brain, causing patients to experience problems with behavior, thinking and involuntary movements. Read More >
Case Study
Research Trend
AAV-CRISPR/Cas9-Mediated Gene Editing - An Efficient Tool for Atherosclerosis Research
Mar 18, 2021
Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and premature cardiovascular disease (CVD). FH is an autosomal dominant genetic disease (with a gene dosage effect) that is caused by mutations in genes encoding low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or subtilisin converting enzyme 9 (PCSK9). Around 90% of FH is caused by LDLR mutations. Read More >
Weekly Gene
Immunology and Inflammation Research - IL17A
Mar 17, 2021
Since IL17A plays an important role in infectious diseases, inflammatory, autoimmune diseases and cancer studies, IL17A has become a hot research target for many studies. In this Gene of the Week article, we have collected some insights on IL17A research progress and development trends, aiming to inspire even more scientific innovations. Read More >