The following publications demonstrate the use of custom genetically modified mouse and rat models across a broad range of human disease studies, including immunological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and liver disease.

Featured Animal Model Publications From 2020

Model Type Used

Research Applications

Gene Target



Conditional Point Mutation (cPM) Mice


Cardiology, gene therapy


Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model

Science Advances

DOI: 10.1126/sciadv.aay5556 (2020)

Knockout (KO) Mice


Neurology, aging


Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline.

Cell Metabolism

PMID: 32004475

Conditional KO (cKO) Mice


Hepatic steatosis, insulin resistance, inflammation


Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder

Advanced Science

DOI: 10.1002/advs.201903657

CRISPR-mediated Knockout (KO) Mice

Immunology, inflammatory disorders


Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation.

Molecular Cell

PMID: 32035036)

Point Mutation Mice


Pde6b rd1

MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells

Mucosal Immunology

DOI: 10.1038/s41385-020-0282-x

PNI-based Transgenic Mice

Skin inflammation, immunology


Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice

Life Science Alliance

PMID: 32086318

Humanized Mice

(PNI-based TG)


Human CRP

C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia.

Journal of Translational Medicine

DOI: 10.1186/s12967-020-02226-x

CRISPR-mediated Knockout (KO) Rat



DPYSL2 Is a Novel Regulator for Neural Stem Cell Differentiation in Rats: Revealed by Panax Notoginseng Saponin Administration

Stem Cell Research & Therapy

DOI: 10.1186/s13287-020-01652-4

Knockout (KO) Rat



A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats.

Endocrine-Related Cancer

PMID: 32252027

Browse All Citations

Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Since our founding in 2005, Cyagen has been cited in over 3,500 publications – all of which are available as a searchable list. 


If you need more information regarding our technologies and how Cyagen can help you further your research, contact us with your gene target(s) and our custom model generation experts will be in touch with you.