From January through June of 2020, Cyagen received over 70 citations for our animal models, contributing to many advances across research fields. We have put together the below list of articles from high impact factor (IF) journals to provide insights into a variety of mouse model types, gene targets, research applications, and some of the most recent developments shown in scientific literature.
The following publications demonstrate the use of genetically modified mouse models across a range of human disease research, including atherosclerosis, inflammatory disorders, cardiovascular disease, oncology, metabolism, and virology. All citations listed feature gene targets included among our ready-to-use Cyagen Knockout Catalog Models – deliverable in as fast as 3 months!
Cyagen Knockout Catalog Models - Featured 2020 Publications
| Mouse Model Type Used | Gene Target | Research Applications | Knockout Catalog Model Link | Title | Journal Information |
| Knockin (KI) | Ldlr | Atherosclerosis | Ldlr KO Mouse | In Vivo AAV-CRISPR-Pro-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. |
Circulation DOI: 10.1161/CIRCULATIONAHA.119.042476 |
| Knockout (KO) | Dapp1 | Thrombopoiesis | Dapp1 KO Mouse | Melatonin Enhances Thrombopoiesis Through ERK1/2 and Akt Activation Orchestrated by Dual Adaptor for Phosphotyrosine and 3-phosphoinositides |
Journal of Pineal Research DOI: 10.1111/jpi.12637 |
| Drd5 | Inflammation | Drd5 KO Mouse | Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation |
Molecular Cell DOI: 10.1016/j.molcel.2020.01.022 |
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| Conditional Knockout (cKO) | Steap4 | Oncology | Steap4 KO Mouse | Inflammation Mobilizes Copper Metabolism to Promote Colon Tumorigenesis via an IL-17-STEAP4-XIAP Axis |
Nature Communications DOI: 10.1038/s41467-020-14698-y |
| Raly | Metabolism | Raly KO Mouse | Collaborative Interactions of Heterogenous Ribonucleoproteins Contribute to Transcriptional Regulation of Sterol Metabolism in Mice |
Nature Communications DOI: 10.1038/s41467-020-14711-4 |
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| Rbck1 | Virology | Rbck1 KO Mouse | Regulation of the Linear Ubiquitination of STAT1 Controls Antiviral Interferon Signaling |
Nature Communications DOI: 10.1038/s41467-020-14948-z |
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| Transgenic | Cxcr4 | Oncology | Cxcr4 KO Mouse | Exosome-encapsulated miRNAs Contribute to CXCL12/CXCR4-induced Liver Metastasis of Colorectal Cancer by Enhancing M2 Polarization of Macrophages |
Cancer Letters DOI: 10.1016/j.canlet.2020.01.005 |
Global Group Buy Event
Cyagen is simultaneously offering a Global Group Buy Event through August 25th – join together with researchers worldwide to save up to $3,000 on orders from Cyagen Knockout Catalog Models. There are three tiers of group buy discounts available - formed by 2, 3, and 5 participants for each knockout (KO) mouse strain available in the catalog.
Save Up to $4,450 on Knockout Catalog Orders – Win a Free Model!
Now through August 31st, order any ready-to-use knockout (KO) strains from the Cyagen Knockout Catalog Model repository to receive 10% off alongside free homozygous breeding services – providing a total savings of $4,450. In addition to the limited-time discount, all projects initiated by the deadline will be entered to win a FREE KO catalog model!
Learn more about this offer by visiting the promotional page: Win a Free KO Model
About Cyagen Biosciences
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas. Since our founding in 2005, Cyagen has been cited in over 4,000 publications – all of which are available as a searchable list.
For a complimentary consultations and quotes, please call 800-921-8930 or email animal-bank@cyagen.com to get in touch with our model generation experts.
