Despite the effects of COVID-19 on global business, we are operating at 100% proficiency - providing uninterrupted production and technical support to ensure that your research continues. We will continue serving your model generation, cloning, virus and packaging needs with the same high quality and fast turnaround as before the outbreak. Cyagen has established strong partnerships worldwide, improved our rigorous safety standards, and maintained full operational efficiency to ensure continuity in research operations for all our clients throughout this critical time.

The experts at Cyagen remain available to support all your research needs, while continuing development of complimentary resources for those seeking accurate animal models for their COVID-19 studies. Below, we have collected some of our key responses that aim to support COVID-19 research and ensure the stability of all ongoing scientific studies.
 

COVID-19 Researchers: Resources and Support

We understand that institutions worldwide are adapting to new measures towards the prevention and control of COVID-19 – all of our project timelines may be adapted to meet your needs. As a leading provider of animal models with a strong basis in social responsibility – Cyagen’s research and development (R&D) team continues to prioritize development of both animal models and technical resources catered to the global COVID-19 research initiative. 

 

Complimentary Letter of Support for COVID-19 Research

When evaluating research funding applications, reviewers will seek to understand the strategies used in generating any research models for your proposal. Cyagen’s model generation experts can provide you with a letter of support for your project, clarifying the key significance of the custom model for your COVID-19 research – furthering the impact of your funding application.

 

How can Cyagen help you?

  • Targeting strategies and quotes provided within 48 hours of request
  • Free project consultation from our scientists
  • Price matching for competitor quotes + an additional 5% discount
  • Complimentary funding support letter for your research project

For more information about available funding for COVID-19 research, technical resources for coronavirus models, and how Cyagen’s animal model experts can support your study, visit our announcement:

>> COVID-19 Research Funding & Grant Application Support

  

ACE2 Mice Pre-Order – Knockout (KO), Humanized (ROSA26 cKI; endogenous)

Cyagen is prioritizing production of ACE2 mice to support research on COVID-19, the disease caused by SARS-CoV-2 virus. We have opened orders for expedited mouse models for ACE2 receptor targets, including knockout (KO) and humanized lines. We aim to generate enough pups to meet the demand for these key models as quickly as possible - early orders will not only receive prioritized delivery, but also help inform our plans for colony expansion.

ACE2 Catalog Models Available for Pre-Sale
Catalog Models Estimated Availability Backgrounds Price ($) per Mouse
ACE2 Knockout (KO) As Fast as 4 Months C57BL/6J $500
BALB/c $650
Humanized Mice (ROSA26 cKI) As Fast as 4 Months C57BL/6J $1,000
BALB/c $1,300
Humanized Mice (Endogenous Replacement) As Fast as 4 Months C57BL/6J $1,200
BALB/c $1,500

For more information, visit: ACE2 Mice – Expedite Your COVID-19 Research Efforts

 

Coronavirus Research in Review: Genetic Targets, Mouse Models, and More

Recent pubCoronavirus Research in Review: Genetic Targets, Mouse Models, and Morelications have focused on the importance of the ACE2 host receptor implicated in SARS-CoV-2 infection, but there are numerous other targets known to play key roles in the pathology of closely-related viruses. In our newest Technical Bulletins, we review the variety of targets pertinent to research efforts against the COVID-19 outbreak, including:

  • ACE2 (Angiotensin-converting enzyme 2)
  • DPP4 (Dipeptidyl peptidase-4)
  • APN (Aminopeptidase N)
  • TMPRSS2 (Transmembrane Serine Protease 2)
  • ADAM17 (ADAM Metallopeptidase Domain 17)
  • LY6E (Lymphocyte Antigen 6 Complex, Locus E)
  • SIGN/CD209L (Cluster of Differentiation 209)
  • CD147 (Cluster of Differentiation 147)
  • DHODH (Dihydroorotate Dehydrogenase)
  • ... and more!

Learn more about the above targets’ roles in coronavirus infections by visiting our Technical Bulletin, which provides a complete listing of our freely-available scientific reviews and resources to support COVID-19 research:

>> Complete Collection: The Hottest Mouse Models for Coronavirus Research 

 

Virtual Consultations for Custom Animal Models

With the emergence of the novel coronavirus (SARS-CoV-2), the meetings, shows, and conferences that allow us to interface with customers in person have been canceled for the foreseeable future. In light of these recent changes, both the Cyagen US and Taconic Biosciences' Model Design Specialist teams are working remotely from home to help do our part to flatten the curve. To better support your research needs, we are readily-available for virtual consultations to discuss custom mouse model design!

 

Our 3-step process will not only help you get moving on a project, but also support your preparations to include your custom model in a grant application:

  1. Initial consultation – 30-minute Teleconference
    • Genetic Engineering Techniques: TurboKnockout®Gene Targeting, CRISPR, PiggyBac Transgenic (TG), PiggyBac-on-BAC TG, etc.
    • Targeting Design Capabilities: Constitutive Knockout (KO), Conditional Knockout (cKO), Point Mutation, Targeted Transgenic (ROSA26, H11, Conditional Overexpression), Large Fragment Knockin (LFKI), and more.
  2. After Teleconference, the Model Design Specialist will provide the following via email within 2-3 business days:
    • Targeting strategy
    • Price Quotation
    • Letter of Support (for funding/grant applications)
  3. Second consultation - 30-60 Minute Teleconference
    • Step-by-Step review of Targeting Strategy with Model Design Specialist

 
With the current social distancing measures that have been put in place, we understand that many labs are reducing to critical staff only. If you're worried about maintaining your live colonies, our team is also available to discuss cryopreservation options to protect your valued genetically engineered models until you are ready for them.

 

 

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Knockout Mice | Ready-to-Use KO Mice Model