BRG
Product Type
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Genotype
Sex
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Basic Information
Model Name
BRG
Product ID
C001436
Background
BALB/cAnCya
Gene Alias
Rag-2; gc; p64; [g]c; CD132; gamma(c)
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “BRG mice (Catalog C001436) were purchased from Cyagen.”
Strain Description
BRG mice are models with the double knockout of Il2rg and Rag2 genes. This model presents more severe depletion of B cells, T cells, and NK cells as well as other severe combined immunodeficiency phenotypes than mice with knockout of either the Il2rg or Rag2 genes alone. BRG mice can be used for research in various fields of oncology and immunology.
Application Area
Oncology: Investigating the mechanisms underlying tumor growth and metastasis, and evaluating the efficacy of antitumor drugs
Immunology: Exploring the mechanisms of immune cell development and maturation, as well as the pathogenesis of immune diseases
Epidemiology: Examining the mechanisms of viral and bacterial infectious disease pathogenesis
Stem Cell Biology: Investigating the potential of human stem cell transplantation
Validation Data