B6-Ighj KO

 

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Item Number: C001344

Background: C57BL/6J

Genotype:  Homozygous

Mouse Status: Homozygous knockout mice are developmentally normal and fertile

In this mouse homozygote, the J-segment of the Ig heavy chain locus is completely deleted, resulting in the inability of the cell to produce a recombinant version of the complete heavy chain variable region. The B cells of Ighj knockout (KO) mice have undergone dramatic changes in developmental process and cell number, which can be used as an animal model of B cell immune deficiency. Ighj KO mice retain other immune cells except B cells, so changes in other immune cells can be detected in Ighj KO mice.



Immunology; Inflammation; Autoimmunity Research.

• Detection of B cells 



Figure 1. Detection of B cells in peripheral blood and spleen of Ighj KO homozygous mice

The results showed that B cell deletion was detected in the peripheral blood and spleen of Ighj KO homozygous mice.

 

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