B6-Ighj KO


>> Request a Quote or Information
Our Experts will contact you providing a quote,
information and estimated timeframe to
your project needs.

Item Number: C001344

Background: C57BL/6JCya

Genotype:  Homozygous

Mouse Status: Homozygous knockout mice are developmentally normal and fertile

In this mouse homozygote, the J-segment of the Ig heavy chain locus is completely deleted, resulting in the inability of the cell to produce a recombinant version of the complete heavy chain variable region. The B cells of Ighj knockout (KO) mice have undergone dramatic changes in developmental process and cell number, which can be used as an animal model of B cell immune deficiency. Ighj KO mice retain other immune cells except B cells, so changes in other immune cells can be detected in Ighj KO mice.

Immunology; Inflammation; Autoimmunity Research.

• Detection of B cells 

Figure 1. Detection of B cells in peripheral blood and spleen of Ighj KO homozygous mice

The results showed that B cell deletion was detected in the peripheral blood and spleen of Ighj KO homozygous mice.


Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.


Inquiries and Quote Requests

Request a quote now. Alternatively, you can always email animal-service@cyagen.com or call 800-921-8930 to inquire about our services or obtain a quote for your project.


About Cyagen

● 15+ years' experience in custom animal model generation
● 78,000+ animal models generated and delivered worldwide
● 6,200+ citations in SCI journals
● 3,000+ university and company partners
 100% money-back guarantee option available for most services
● AAALAC-Accredited and OLAW Assured