B6-Ighm KO


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Item Number:C001340


Genotype:  Homozygous
Mouse Status: Homozygous knockout mice are developmentally normal and fertile

Immunoglobulin M (IgM) is an essential antibody secreted by B lymphocytes which is the first antibody expressed on the membrane of developing cells. Immature B cells begin to express mIgM, but if they bind to antigens, they will produce a negative response, changing B cells into a suppressed state where they become unable to continue to differentiate into mature B cells, which results in autoimmune tolerance. Ighm KO homozygous mice lack mature B cells, thus providing this mechanism of autoimmune tolerance.

Exon 1~6 with Ighm gene knocked out.

Immunology; Inflammation; Autoimmunity Research.

• Loss of Ighm expression

Figure 1. Loss of Ighm expression in peripheral blood, spleen and bone marrow cells of Ighm-KO homozygous mice

The results showed that Ighm expression was not detected in peripheral blood, spleen and bone marrow cells of Ighm-KO homozygous mice.

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