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Citations
IMMUNITY 47:107 (2017) IF=22.845
You may also be interested in
Item Number：C001340
Background：C57BL/6J
Genotype: Homozygous
Mouse Status: Homozygous knockout mice are developmentally normal and fertile
Immunoglobulin M (IgM) is an essential antibody secreted by B lymphocytes which is the first antibody expressed on the membrane of developing cells. Immature B cells begin to express mIgM, but if they bind to antigens, they will produce a negative response, changing B cells into a suppressed state where they become unable to continue to differentiate into mature B cells, which results in autoimmune tolerance. Ighm KO homozygous mice lack mature B cells, thus providing this mechanism of autoimmune tolerance.
Exon 1~6 with Ighm gene knocked out.
Immunology; Inflammation; Autoimmunity Research.
• Loss of Ighm expression
Figure 1. Loss of Ighm expression in peripheral blood, spleen and bone marrow cells of Ighm-KO homozygous mice
The results showed that Ighm expression was not detected in peripheral blood, spleen and bone marrow cells of Ighm-KO homozygous mice.
Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.
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