B6J-Ighm Ighd-DKO

 

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Item Number:C001342
Background:C57BL/6J
Genotype:  Homozygous
Mouse Status: Homozygous knockout mice are developmentally normal and fertile

Surface membrane immunoglobulin (SmIg) of B cell membrane is a receptor that specifically recognizes antigens of B cells, and it is also an important characteristic marker of B cells. Early immature B cells express immunoglobulin M (IgM), while mature B cells express both mIgM and mIgD. Ighm Ighd-DKO homozygous mice lack mature B cells and can be used as an animal model of B cell immunodeficiency.

 mouse model has knocked out Ighm gene exon 1~6 and Ighd gene exon 1~5.



Immunology; Inflammation; Autoimmunity Research.

• Detection of B cells 


Figure 1. Detection of B cells in peripheral blood and spleen of Ighm Ighd-DKO homozygous mice.

The results showed that B cell depletion was detected in the peripheral blood and spleen of Ighm Ighd-DKO homozygous mice.

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