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- ● Diet-induced obesity (DIO) Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model
- ● Chemically Induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model
- ● Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Non-alcoholic Fatty Liver Disease (NAFLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
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Citations
IMMUNITY 47:107 (2017) IF=22.845
Gene Aliases: TRA, TRA@
Item Number：C001332
Background：C57BL/6J
Genotype: Homozygous
Mouse Status: Homozygous knockout mice are developmentally normal and fertile
T-cell receptors (TCRs) recognize foreign antigens that have been processed into small peptides and bound by the major histocompatibility complex (MHC) on the surface of antigen-presenting cells (APCs). Each T cell receptor is a dimer consisting of either an alpha chain and a beta chain, or a delta chain and a gamma chain. The TRA gene encodes the TCR alpha locus.
Homozygous mice with Tra knockout (KO) will lack the αβ T cell receptor and the thymus lacks CD4+CD8- and CD4-CD8+ cells, which retains about 1.5% of thymocytes that express the T cell receptor γδ.
Knockout of Trac gene (Gene ID: 100101484) exon 1-3.
Immunology; Inflammation; Autoimmunity Research.
• Detection of T cells in the thymus of Tra KO mice
Figure 1. Detection of T cells in the thymus of Tra KO mice
• Detection of T cells in blood and spleen of Tra KO mice
Figure 2. Detection of T cells in blood and spleen of Tra KO mice
The results showed that Tra KO mice lacked αβ T cell receptors after knockout of Tra gene, and the thymus did not develop CD4+CD8- and CD4-CD8+ single positive cells. Given that T cells include αβ T cells and γδ T cells, of which γδ T cells account for 0.5-5% of all T lymphocytes, the residual CD3+ T cells may be γδ T cells.
Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.
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