B6-Tcra KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-Tcra KO
Product ID
C001332
Gene Name
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Background
C57BL/6JCya
Gene Alias
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Classification
Immunodeficient Mouse Models
NCBI ID
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Phenotype
Chromosome
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More
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Document
Note: When using this mouse strain in a publication, please cite “B6-Tcra KO mice (Catalog C001332) were purchased from Cyagen.”
Strain Description
This strain is a Tcra gene deletion model in which homozygous B6-Tcra KO mice with αβ T-cell receptor deficiency have thymuses lacking CD4+CD8- and CD4-CD8+ cells, and approximately 1.5% of thymocytes express γδ T-cell receptors. homozygous B6-Tcra KO mice are developmentally normal and fertile, but mortality increases after 6 months, and few mice survive beyond one year.
Application Area
Study of Immunological, inflammatory, and autoimmune diseases
Validation Data