Preclinical Mouse Models
With 20 years of genetic engineering expertise, Cyagen provides a catalog of more than 40,000 rodent strains, including HUGO-GT™ humanized, knockout, and conditional knockout lines and preclinical disease models, across 20+ research areas. Every model is produced in AAALAC-accredited facilities and backed by genotype data, so you can go straight from model selection to preclinical studies.
Overview of Cyagen's Preclinical Rodent Models
Cyagen works with more than 10,700 research institutions in over 100 countries and regions, and studies using our models have been cited in 16,500+ peer-reviewed publications. Our model development capabilities combine proprietary ES cell-based TurboKnockout™ gene-targeting technology, BAC engineering, and other advanced gene editing approaches. These technologies support the generation of knockout and conditional knockout models, targeted mutations, and humanized gene replacements. Our HUGO-GT™ platform further enables full-length human gene replacement to support research involving human-specific genomic sequences and disease-associated variants.
Cyagen operates research and production facilities across Suzhou, Guangzhou, and Gu'an, with over 40,000 m² of combined research and production space. SPF barrier facilities support more than 150,000 individually ventilated cages (IVCs). Cyagen maintains AAALAC International accreditation, ISO 9001:2015 quality management certification, and an OLAW-approved Animal Welfare Assurance.
Cyagen supports its research models with genetic quality control, model-specific characterization, and routine animal health monitoring.
● Genetic validation: PCR-based genotyping and sequence confirmation of engineered alleles during model development, as applicable
● Expression validation: Model-dependent assessment of RNA and protein expression using RT-qPCR, Western blot, flow cytometry, or other appropriate assays
● Functional validation: disease-relevant phenotyping, functional assessments, and reference-compound studies, including pharmacological response data for selected models
● Health monitoring: routine SPF health surveillance, with health reports provided
Across oncology, neuroscience, immunology and inflammation, metabolism, and ophthalmology, our preclinical disease models are built to support target validation, efficacy testing and mechanism-of-action studies. Cyagen reports more than 16,500 SCI citations and over 10,700 research partners worldwide. Explore the categories below to find the right model for your program.
Research Infrastructure and Quality Standards
Cyagen operates research and production facilities across Suzhou, Guangzhou, and Gu'an, with over 40,000 m² of combined research and production space. SPF barrier facilities support more than 150,000 individually ventilated cages (IVCs). Cyagen maintains AAALAC International accreditation, ISO 9001:2015 quality management certification, and an OLAW-approved Animal Welfare Assurance.
Model Quality Control and Characterization
Cyagen supports its research models with genetic quality control, model-specific characterization, and routine animal health monitoring.
● Genetic validation: PCR-based genotyping and sequence confirmation of engineered alleles during model development, as applicable
● Expression validation: Model-dependent assessment of RNA and protein expression using RT-qPCR, Western blot, flow cytometry, or other appropriate assays
● Functional validation: disease-relevant phenotyping, functional assessments, and reference-compound studies, including pharmacological response data for selected models
● Health monitoring: routine SPF health surveillance, with health reports provided
Research Models Across Key Research Areas
Across oncology, neuroscience, immunology and inflammation, metabolism, and ophthalmology, our preclinical disease models are built to support target validation, efficacy testing and mechanism-of-action studies. Cyagen reports more than 16,500 SCI citations and over 10,700 research partners worldwide. Explore the categories below to find the right model for your program.
HUGO-GT™ Humanized Mice
Full-gene humanization to study human diseases with greater accuracy.
Humanized Target Gene Models
Mice carrying human gene sequences for studying gene function and drug responses.
Ophthalmic Disease Models
Models of retinal and macular disorders for vision research.
Neurological Disease Models
Models of neurodegenerative and neurodevelopmental disorders.
Autoimmune Disease Models
Models replicating SLE, RA, and other autoimmune pathologies.
Metabolic Disease Models
Models for diabetes, obesity, and lipid metabolism research.
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