B6-hCD47
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hCD47
Product ID
C001419
Gene Name
Background
C57BL/6JCya
Gene Alias
IAP; OA3; MER6
Classification
Tumor Target Humanized Models,Immune Target Humanized Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “B6-hCD47 mice (Catalog C001419) were purchased from Cyagen.”
Strain Description
B6-hCD47 mice are obtained by replacing the fragment encoding the extracellular domain of CD47 protein in the mouse Cd47 gene with the corresponding human CD47 gene sequence, resulting in a model expressing the extracellular domain of human CD47 protein and the intracellular domain of mouse CD47 protein. This ensures normal binding with human antibodies and other protein drugs while completely retaining the intracellular part of mouse CD47 protein, maintaining normal intracellular signal transduction. B6-hCD47 mice can successfully express human CD47 protein and can be used for research on CD47-targeted inhibitors or antibody drug development and screening, pharmacology and safety evaluation, tumor immunotherapy evaluation, and mechanisms of tumor immune escape systems.
Application Area
Development and screening of targeting CD47 inhibitors/antibody drugs
Evaluation of the efficacy and safety of targeting CD47 inhibitors/antibodies
Evaluation of tumor immunotherapy and research on tumor immune escape mechanisms
Validation Data