Foxj1 KO
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Strain Description
Foxj1 (forkhead-box J1), also known as hepatocyte nuclear factor-3 (HNF-3) or forkhead homologue-4 (HFH-4), is a member of the forkhead-box transcription factor family, a class of transcription factors with a winged helix structure that binds to DNA. The Foxj1 factor plays a major regulatory role in controlling the transcription process of motile cilia synthesis. Airway cilia quickly clear airway mucus by swinging, playing a role in resisting pathogen invasion. It also has an effect on the left-right axis asymmetry of organ development during the embryonic period. Studies have shown that Foxj1 KO mice exhibit left-right asymmetric development and airway ciliated epithelium is lost in adult mice. The heterozygous Foxj1 KO mice are viable, while the homozygous mice are lethal.
Application Area
Research on Kartagener syndrome
Research on primary ciliary dyskinesia
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