Uox KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Uox KO
Product ID
C001232
Gene Name
Background
C57BL/6JCya
Gene Alias
--
Classification
Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “Uox KO mice (Catalog C001232) were purchased from Cyagen.”
Strain Description
This strain is a uricase-deficient mouse line generated by knocking out the mouse Uox gene. Due to impaired uricase synthesis, these mice spontaneously exhibit a hyperuricemic phenotype. Heterozygous Uox KO mice are viable and fertile. Homozygous Uox KO mice require allopurinol or similar drugs for postnatal survival.
Application Area
Hyperuricemia Research
Gout and Related Disease Research
Other Metabolic and Renal Disease Research
Validation Data