B6-hVEGFA/hANGPT2
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hVEGFA/hANGPT2
Product ID
C001691
Background
C57BL/6JCya
Gene Alias
VPF; VEGF; MVCD1; L-VEGF; ANG2; AGPT2; LMPHM10
Classification
Tumor Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Ophthalmic Disease Models
Phenotype
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “B6-hVEGFA/hANGPT2 mice (Catalog C001691) were purchased from Cyagen.”
Strain Description
B6-hVEGFA/hANGPT2 mice are VEGFA and ANGPT2 double humanized mouse models obtained by mating VEGFA humanized mouse models (Catalog No. C001555) with ANGPT2 humanized mouse models (Catalog No. C001615). B6-hVEGFA/hANGPT2 mice express human VEGFA and ANGPT2 genomic sequences under the control of mouse promoters. This model is capable of reproducing human VEGFA and ANGPT2 and is a valuable tool for studying cancer, vascular diseases and autoimmune disorders. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting VEGFA and ANGPT2.
Application Area
VEGFA/ANGPT2-targeted drug screening, development, and evaluation
Mechanistic studies of tumorigenesis and cancer progression
Pathogenesis of vascular diseases and autoimmune disorders
Validation Data