B6-hTARDBP
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hTARDBP
Product ID
C001418
Gene Name
Background
C57BL/6JCya
Gene Alias
ALS10; TDP-43
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “B6-hTARDBP mice (Catalog C001418) were purchased from Cyagen.”
Strain Description
To advance TARDBP-targeted drug therapies, especially gene and oligonucleotide therapies, Cyagen has independently developed a mouse Tardbp gene humanized model, which replaces the mouse Tardbp gene with the human TARDBP gene through gene editing technology. It can be used to study neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia. The homozygous B6-hTARDBP mice are viable and fertile.
Application Area
Research on amyotrophic lateral sclerosis (ALS)
Research on frontotemporal dementia (FTD)
Research on other neurodegenerative diseases
Validation Data