B6-hRHO-P23H
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Basic Information
Model Name
B6-hRHO-P23H
Product ID
C001495
Gene Name
Background
C57BL/6JCya
Gene Alias
RP4; OPN2; CSNBAD1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “B6-hRHO-P23H mice (Catalog C001495) were purchased from Cyagen.”
Strain Description
This strain is a mouse Rho gene humanized model, in which the endogenous mouse Rho gene is replaced by the human RHO gene carrying a P23H mutation to express human retinal proteins in mice. Therefore, the abnormal protein encoded by the human gene was expressed in mice, resulting in abnormal retinal appearance and function and visual defects in this model.
Application Area
Research on retinitis pigmentosa (RP)
Research on congenital stationary night blindness (CSNB)
Research on other retinal diseases
Validation Data