Comprehensive Alzheimer's Disease CRO Solutions for Drug Discovery
Tackle the complex challenges of Alzheimer's Disease with Cyagen's integrated research platform. We combine validated animal models, end-to-end CRO services, and expert-led strategy to accelerate the discovery of new AD therapeutics for scientists worldwide.
An Integrated Approach to AD Research & Its Challenges
Alzheimer's is the world's leading neurodegenerative disease, with a severe epidemiological outlook and vast unmet medical needs. While progress has been made in understanding key pathogenic mechanisms like Aβ plaques, tauopathy, and neuroinflammation, preclinical research still faces critical bottlenecks, including poor clinical translatability of models and a lack of standardized efficacy evaluation criteria.
To address these complex challenges, Cyagen has developed a powerful and integrated research platform.
Our portfolio of specialized animal models, combined with comprehensive in vivo and in vitro services
detailed below, provides the critical tools scientists need to overcome these hurdles and accelerate
their discovery programs.
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Our comprehensive portfolio of Alzheimer's Disease (AD) models is organized by
key pathological targets to help you find the most relevant tools for your research. The table
below includes both our validated, ready-to-use models for immediate deployment, and our
advanced R&D platforms for foundational models like APP and APOE4, available for custom projects
and collaborative research.
| Target Class | Model Name | Key Features | Status | Details |
|---|---|---|---|---|
| Tauopathy | B6-htau | Humanized MAPT (Wild-Type) | Ready-to-Use | View |
| B6-htau*P301L | Humanized MAPT (P301L Mutation) | Ready-to-Use | View | |
| B6-htau*P301S | Humanized MAPT (P301S Mutation) | Ready-to-Use | View | |
| B6-hTFRC/htau | Humanized TFRC & MAPT (WT) | Ready-to-Use | View | |
| B6-hTFRC/htau*P301L | Humanized TFRC & MAPT (P301L) | Ready-to-Use | View | |
| B6-hTFRC/htau*P301S | Humanized TFRC & MAPT (P301S) | Ready-to-Use | View | |
| B6-htau/hGLP-1R | Humanized MAPT & GLP-1R (WT) | Ready-to-Use | View | |
| Aβ Pathology | hAPP | Humanized APP (Wild-Type) | R&D | - |
| hAPP (NL-G-F-V) | Humanized APP (Swedish/Iberian/Arctic) | R&D | - | |
| Key AD Risk Gene | B6-hAPOE4 | Humanized APOE4 (Wild-Type) | R&D | - |
| Neuroinflammation | Trem2 KO | Trem2 Knockout | Ready-to-Use | View |
| hTREM2 | Humanized TREM2 (Wild-Type) | R&D | - |
Can't find the model you need?
Explore hundreds of additional off-the-shelf neuroscience models in our MouseAtlas database, or partner with
our scientific team to develop a custom-engineered model tailored to your exact research
specifications.
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Precision Drug Administration
Our team of skilled specialists is highly experienced in precision injection
methodologies tailored for CNS research. We offer a comprehensive array of validated
administration routes to ensure accurate and reliable delivery of your therapeutic
candidates.
- Systemic Delivery: Intravenous (tail vein), Intraperitoneal, Subcutaneous, etc.
- CNS-Targeted Delivery: Stereotactic brain injection, Intrathecal injection, Intraventricular injection, and Intranasal administration.
Featured Technique: Stereotactic Brain Injection
Our stereotactic injection service enables targeted delivery to specific brain
regions critical to AD pathology, such as the hippocampus and cortex, guided by 3D coordinates
and verified through histological imaging.
Case Study: AAV Delivery to the CNS
Agent: AAV9-CMV-EGFP-HGH
Coordinates: -2mm, ±1.8mm, -1.5mm
Titer: 1.98×10¹⁴ vg/mL
Dose: 1×10¹⁰ vg/0.5μL/site
Imaging Time: 4 weeks post-injection
Figure: Precise injection site visualization using
the brain stereotactic
instrument.
Case Study: LPS-Induced Neuroinflammation Model
Agent: Lipopolysaccharide
Coordinates: +4.8mm, ±1.8mm, -8.0mm
Dose: 4μL/site (5 mg/mL)
Observation Time: 2 weeks post-injection
Observation: Rat displaying unidirectional rotational
movement 14
days post-operation.
Figure: Significant behavioral changes observed 2
weeks post-injection.
Neurobehavioral Assessment for AD
We provide a focused suite of behavioral paradigms essential for evaluating the core cognitive
and functional deficits associated with Alzheimer's Disease.
| Behavioral Domain | Recommended Tests for AD Research | Function Tested |
|---|---|---|
| Learning & Memory | Morris Water Maze | Spatial learning and memory |
| Y-Maze | Spatial working memory | |
| Novel Object Recognition | Recognition memory | |
| Fear Conditioning Test | Associative fear memory | |
| Anxiety & Depression-like Behavior | Elevated Plus Maze | Anxiety-like behavior |
| Open Field Test | Locomotor activity and anxiety | |
| Motor Function & Coordination | Rotarod Test | Motor coordination, balance, and ataxia |
| General Well-being | Nest Building | Assessment of well-being and cognitive decline |
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We offer a focused suite of analytical services to investigate the core
pathological and molecular features of Parkinson's Disease, and to evaluate the efficacy of
your therapeutic candidates.
| Analysis Category | Specific Services | Key Applications & Targets in AD Research |
|---|---|---|
| Pathology & Biomarker Analysis | Histology & Special Stains (H&E, Congo Red) | Visualize general brain morphology and specifically identify dense-core amyloid plaques. |
| Immunohistochemistry (IHC) / Immunofluorescence (IF) | Detect, localize, and quantify key pathological proteins directly in tissue sections (e.g., Aβ, p-Tau, Iba1 for microglia, GFAP for astrocytes). | |
| ELISA & Immunoassays | Accurately quantify levels of soluble/insoluble Aβ40/42, total Tau/p-Tau, and key inflammatory markers (e.g., cytokines) in brain tissue and plasma. | |
| Gene & Protein Expression | Western Blot | Assess changes in protein levels and post-translational modifications (e.g., phosphorylation of Tau) for key biomarkers. |
| RT-PCR & qPCR | Analyze the expression of target genes (e.g., APP, MAPT), inflammatory factors, and synaptic markers to understand mechanistic changes. | |
| Physiological & Biochemical Analysis | Biochemical Panels | Assess the systemic impact of AD and therapeutic interventions by analyzing immune factors, antioxidant status, blood glucose, and lipid profiles. |
| Metabolic Testing (ITT, GTT) | Evaluate metabolic dysregulation, a known comorbidity and potential driver of AD pathology. |
Case Studies
Explore how we leverage our precision animal models and comprehensive service platforms to provide robust,
decision-enabling data for our partners' AD drug discovery programs.
Case Study 1: Profiling Aβ Pathology & Cognitive Decline in Amyloid Models
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Case Study 2: Drug Efficacy Evaluation in the APP/PS1 Model
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Case Study 3: Pathological Validation of hMAPT Models
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Why Partner with Cyagen?
Comprehensive Model Solutions
Access a portfolio of ready-to-use, validated models and leverage our deep expertise in developing custom models on classic AD backgrounds.
Integrated Efficacy Platform
Utilize our one-stop, standardized services, from in-life behavioral studies to terminal molecular pathology.
Data-Driven Decision Support
Rely on our stringent quality control and commitment to reproducibility to deliver reliable data that supports your critical project decisions.
Expert-Led Study Design
Collaborate with our team of senior scientists to receive end-to-end support, from model selection to customized experimental protocol design.
Related Resources
Events & Webinars
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Cyagen Trailblazer Grant Award – Funding the Frontier of Model Generation
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Blogs & Insights
Driving Translational Success: A Strategic Analysis of C3 and C5 Humanized Mouse Models for Next-Generation Drug Development
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Resource Valut
One-Stop Neuropharmacology CRO Solutions
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Request a Preclinical CRO Services Consultation
Partner with Cyagen to advance your preclinical studies. Share your project goals with us and receive customized support.
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