B6-hIL-17A
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hIL-17A
Product ID
C001510
Gene Name
Background
C57BL/6NCya
Gene Alias
IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
6
Document
Note: When using this mouse strain in a publication, please cite “B6-hIL-17A mice (Catalog C001510) were purchased from Cyagen.”
Strain Description
B6-hIL-17A mice are humanized mouse models that express human IL-17A protein. They were constructed by using gene editing technology to replace the sequence encoding the endogenous extracellular domain of the mouse Il17a gene with the corresponding sequence from the human IL17A gene while retaining the mouse signal peptide. This strain can be used for mechanism research and preclinical evaluation of therapeutic drugs for various chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis. The homozygotes are viable and fertile.
Application Area
Research on multiple chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis
Preclinical evaluation of IL17A-neutralizing antibodies and small molecule inhibitors
More autoimmune disease research
Validation Data