B6-hGDF15
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hGDF15
Product ID
C001520
Gene Name
Background
C57BL/6JCya
Gene Alias
HG; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
Classification
Tumor Target Humanized Models,Metabolic Target Humanized Models,Cytokine Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
19
Document
Note: When using this mouse strain in a publication, please cite “B6-hGDF15 mice (Catalog C001520) were purchased from Cyagen.”
Strain Description
This strain is a mouse Gdf15 gene humanized model expressing human GDF15 protein obtained by replacing the sequence encoding the endogenous structural domain in the mouse Gdf15 gene with the sequence encoding the structural domain in the human GDF15 gene. B6-hGDF15 mice can be used for research on metabolic diseases, cardiovascular diseases, tumor occurrence and development, etc., to assist in the preclinical evaluation of GDF15-targeted drugs.
Application Area
Research on cardiovascular diseases such as heart disease
Research on metabolic diseases such as diabetes and anorexia
Research on colorectal cancer, prostate cancer, and other cancers
Preclinical evaluation of GDF15-targeted drugs
Validation Data