B6-hUSH2A (E10-15)
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hUSH2A (E10-15)
Product ID
C001554
Gene Name
Background
C57BL/6JCya
Gene Alias
US2; RP39; USH2; dJ1111A8.1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “B6-hUSH2A (E10-15) mice (Catalog C001554) were purchased from Cyagen.”
Strain Description
The B6-hUSH2A (E10-15) mouse model, in which the corresponding mouse Ush2a gene sequence was replaced with human USH2A exons 10 to 15 and their flanking regions, provides a valuable tool for studying USH pathogenesis and evaluating preclinical treatments. Homozygous B6-hUSH2A (E10-15) mice are viable and fertile, making them suitable for drug evaluation and disease modeling.
Application Area
Investigation of the pathogenic mechanisms underlying Usher syndrome (USH) and preclinical evaluation of therapeutic drugs
Development, screening, and preclinical evaluation of drugs targeting USH2A
Validation Data