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B6-hTFRC (CDS)
Product ID:
C001584
Background:
C57BL/6NCya
Documents:
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Strain Description
The B6-hTFRC (CDS) mouse model was generated by inserting the human TFRC gene sequence into the mouse Tfrc gene locus using gene-editing technology. To minimize interference from mouse gene sequences or proteins, part of the mouse Tfrc gene sequence was knocked out, resulting in a model expressing only the human TFR1 protein. This model is valuable for studying iron metabolism disorders, neurodegenerative diseases, and tumor development, supporting the development of TFR1-targeted therapeutics and preclinical pharmacological evaluations.
Application Area
Area
Studies on iron metabolism disorders, neurodegenerative diseases, and tumor development
Area
Development, screening, and efficacy evaluation of TFRC-targeted therapies
Area
Research and evaluation of drug delivery across the blood-brain barrier (BBB)
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