B6-hTFRC (CDS)
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hTFRC (CDS)
Product ID
C001584
Gene Name
Background
C57BL/6NCya
Gene Alias
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
Classification
Other Target Humanized Models,Neurological Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hTFRC (CDS) mice (Catalog C001584) were purchased from Cyagen.”
Strain Description
The B6-hTFRC (CDS) mouse model was generated by inserting the human TFRC gene sequence into the mouse Tfrc gene locus using gene-editing technology. To minimize interference from mouse gene sequences or proteins, part of the mouse Tfrc gene sequence was knocked out, resulting in a model expressing only the human TFR1 protein. This model is valuable for studying iron metabolism disorders, neurodegenerative diseases, and tumor development, supporting the development of TFR1-targeted therapeutics and preclinical pharmacological evaluations.
Application Area
Studies on iron metabolism disorders, neurodegenerative diseases, and tumor development
Development, screening, and efficacy evaluation of TFRC-targeted therapies
Research and evaluation of drug delivery across the blood-brain barrier (BBB)
Validation Data