B6-hXDH
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hXDH
Product ID
C001586
Gene Name
Background
C57BL/6NCya
Gene Alias
XO; XOR; XAN1
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “B6-hXDH mice (Catalog C001586) were purchased from Cyagen.”
Strain Description
This strain is a humanized mouse model of the Xdh gene, generated by replacing the mouse Xdh gene with the complete human XDH gene sequence, including its untranslated regions (UTRs), exons, and introns. The B6-hXDH mice express the human XDH gene and xanthine oxidase protein in a pattern similar to the endogenous Xdh gene in mice, making their genetic, protein expression, and biochemical features highly comparable to humans. This strain serves as an ideal preclinical platform for studying the pathological mechanisms of hyperuricemia and gout and for developing novel xanthine oxidase inhibitors and nucleic acid therapies.
Application Area
investigating the pathological mechanisms of hyperuricemia and gout, as well as for screening, developing, and evaluating the efficacy of targeted therapies
Validation Data