B6-hGIPR/hGLP-1R
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Basic Information
Model Name
B6-hGIPR/hGLP-1R
Product ID
C001599
Background
C57BL/6NCya
Gene Alias
PGQTL2; GLP-1; GLP-1R; GLP-1-R
Classification
Metabolic Target Humanized Models,Metabolic Disease Models
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hGIPR/hGLP-1R mice (Catalog C001599) were purchased from Cyagen.”
Strain Description
The B6-hGIPR/hGLP-1R mouse is a dual humanized model for Gipr and Glp1r genes. Using gene-editing technology, a partial coding sequence (CDS) of the human GIPR gene was inserted into the mouse Gipr gene sequence in B6-hGLP-1R mice (Catalog No.: C001421). This model expresses the functional region of the human GIPR protein while preserving the mouse signal peptide. It can be used to study the pathogenic mechanisms of metabolic diseases such as obesity and type 2 diabetes, and the development of GIPR/GLP-1R dual agonist drugs. The homozygotes are viable and fertile.
Application Area
Pathogenesis of obesity and type 2 diabetes
Drug development for obesity and type 2 diabetes
Research on other metabolic diseases such as cardiovascular and myocardial diseases
Study of the neuroprotective effect in nervous system diseases
Validation Data