B6-hATP7B*H1069Q
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Strain Description
This strain is a humanized point mutation model constructed by introducing the common pathogenic mutation p.H1069Q (CAC>CAA) into the humanized ATP7B gene of B6-hATP7B mice (Catalog No.: I001130). This model is suitable for studying the pathogenic mechanisms of Wilson's disease, and homozygous animals are viable and fertile.
Application Area
Research on hepatolenticular degeneration (HLD)
Preclinical evaluation of ATP7B-targeted drugs
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