B6-hPCSK9
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Genotype
Sex
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Basic Information
Model Name
B6-hPCSK9
Product ID
C001617
Background
C57BL/6NCya
Gene Alias
FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; Apo-E
Classification
Metabolic Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models,Autoimmune Disease Models
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hPCSK9 mice (Catalog C001617) were purchased from Cyagen.”
Strain Description
B6-hPCSK9 mice are a humanized model generated by gene editing technology to replace the mouse Pcsk9 gene with the human PCSK9 gene sequence. These mice express human PCSK9 protein and can be used for research on various metabolic diseases, neurodegenerative diseases, tumor development, autoimmune disease mechanisms, and for the preclinical pharmacological evaluation of PCSK9-targeted drugs. In addition, Cyagen has developed a similar model, the B6-hPCSK9(CDS) mouse (PCSK9 coding sequence humanized model, Catalog Number: C001593). Compared to the B6-hPCSK9 mouse model, the B6-hPCSK9(CDS) mouse expresses higher levels of human PCSK9 and exhibits LDLR protein expression closer to physiological levels. It is recommended to choose the appropriate model based on the type of drug or research direction.
Application Area
Development and screening of PCSK9-targeted therapies
Preclinical pharmacological and efficacy evaluation of PCSK9-targeted therapies
Research on metabolic diseases such as hypercholesterolemia, atherosclerosis, and coronary heart disease
Research on neurodegenerative diseases such as stroke and Alzheimer's disease
Validation Data