B6-hCD20
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCD20
Product ID
C001625
Gene Name
Background
C57BL/6NCya
Gene Alias
B1; S7; Bp35; CD20; FMC7; CVID5; LEU-16
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “B6-hCD20 mice (Catalog C001625) were purchased from Cyagen.”
Strain Description
The B6-hCD20 mouse is a humanized model generated using gene editing technology to replace the entire base sequence of the mouse Ms4a1 gene in situ with the corresponding sequence from the human MS4A1 gene. Homozygous B6-hCD20 mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of autoimmune diseases and cancers, and for the screening, development and preclinical efficacy and safety evaluation of CD20-targeted drugs.
Application Area
Screening, development and preclinical efficacy and safety evaluation of CD20-targeted therapies
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases and cancers
Validation Data