B6-hTL1A/hNLRP3
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Genotype
Sex
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Basic Information
Model Name
B6-hTL1A/hNLRP3
Product ID
C001690
Gene Name
Background
C57BL/6N;6JCya
Gene Alias
AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL
Classification
Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hTL1A/hNLRP3 mice (Catalog C001690) were purchased from Cyagen.”
Strain Description
B6-hTL1A/hNLRP3 mice are TL1A and NLRP3 double humanized mouse models obtained by mating TL1A humanized mouse models (Catalog No. C001603) with NLRP3 humanized mouse models (Catalog No. C001616) . B6-hTL1A/hNLRP3 mice express human TL1A and NLRP3 genomic sequences under the control of mouse promoters. This model is capable of reproducing human TL1A and NLRP3 and is a valuable tool for studying autoimmune diseases and inflammation-related diseases. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting TL1A and NLRP3.
Application Area
TL1A/NLRP3-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases and inflammation-related diseases
Validation Data