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B6-hTL1A/hNLRP3
Product ID:
C001690
Background:
C57BL/6N;6JCya
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Strain Description
B6-hTL1A/hNLRP3 mice are TL1A and NLRP3 double humanized mouse models obtained by mating TL1A humanized mouse models (Catalog No. C001603) with NLRP3 humanized mouse models (Catalog No. C001616) . B6-hTL1A/hNLRP3 mice express human TL1A and NLRP3 genomic sequences under the control of mouse promoters. This model is capable of reproducing human TL1A and NLRP3 and is a valuable tool for studying autoimmune diseases and inflammation-related diseases. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting TL1A and NLRP3.
Application Area
Area
TL1A/NLRP3-targeted drug screening, development, and evaluation
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Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases and inflammation-related diseases
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