B6-hCD3/hBCMA
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Genotype
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Basic Information
Model Name
B6-hCD3/hBCMA
Product ID
C001833
Background
C57BL/6NCya
Gene Alias
T3E; TCRE; IMD18; CD3epsilon; T3D; IMD19; CD3DELTA; CD3-DELTA; T3G; IMD17; CD3GAMMA; CD3-GAMMA; BCM; BCMA; CD269; TNFRSF13A
Classification
Immune Target Humanized Models
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hCD3/hBCMA mice (Catalog C001833) were purchased from Cyagen.”
Strain Description
The B6-hCD3/hBCMA mouse is a dual-gene humanized model generated by crossing B6-hCD3 mice (Catalog No.: C001325) with B6-hBCMA (TNFRSF17) mice (Catalog No.: C001630). This model can be used for researching the pathological mechanisms and therapeutic approaches of diseases such as autoimmune diseases and multiple myeloma, as well as for the development of CD3/BCMA-targeted drugs.
Application Area
Screening, development, and preclinical efficacy and safety evaluation of CD3/BCMA-targeted drugs
Research on T cell activation and antigen recognition
Research on immunosuppressive therapies for autoimmune diseases
Research on the pathological mechanisms and therapeutic approaches of multiple myeloma, systemic lupus erythematosus (SLE), and various B cell-related diseases
Validation Data