SD-Rosa-hAGT/H11-hREN
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
SD-Rosa-hAGT/H11-hREN
Product ID
CR007
Background
SD
Gene Alias
ANHU; hFLT1; SERPINA8; RTD; HNFJ2; ADTKD4
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “SD-Rosa-hAGT/H11-hREN mice (Catalog CR007) were purchased from Cyagen.”
Strain Description
The SD-Rosa-hAGT/H11-hREN rats are a humanized model obtained by mating SD-Rosa-hAGT rats with SD-H11-hREN rats. This model can be used for research on the regulation of blood pressure, body fluid and electrolyte homeostasis, and the pathological mechanisms and treatment methods of primary hypertension, preeclampsia, renal tubular hypoplasia, non-familial structural atrial fibrillation, inflammatory bowel disease, etc. Moreover, it can be applied to the development of antihypertensive drugs targeting the renin-angiotensin system (RAS).
Application Area
Development, screening, and safety evaluation of antihypertensive drugs targeting the renin-angiotensin system (RAS)
Research on homeostatic regulation of blood pressure, body fluids, and electrolytes
Research on primary hypertension and preeclampsia
Research on renal tubular dysplasia
Validation Data