The SD-Rosa-hAGT/H11-hREN rats are a humanized model obtained by mating SD-Rosa-hAGT rats with SD-H11-hREN rats. This model can be used for research on the regulation of blood pressure, body fluid and electrolyte homeostasis, and the pathological mechanisms and treatment methods of primary hypertension, preeclampsia, renal tubular hypoplasia, non-familial structural atrial fibrillation, inflammatory bowel disease, etc. Moreover, it can be applied to the development of antihypertensive drugs targeting the renin-angiotensin system (RAS).