FRG
Product Type
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Genotype
Sex
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Basic Information
Model Name
FRG
Product ID
I001126
Background
C57BL/6JCya
Gene Alias
swst; Rag-2; gc; p64; [g]c; CD132; gamma(c)
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
7
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Note: When using this mouse strain in a publication, please cite “FRG mice (Catalog I001126) were purchased from Cyagen.”
Strain Description
FRG mice are obtained by crossing Fah KO mice (Catalog No.: C001273) with B6RG mice (Rag2 and Il2rg double knockout mice, Catalog No.: C001367). Research shows that FRG mice (triple knockout of Fah, Rag, and Il2rg), developed by mating Fah KO mice with Rag2 KO and Il2rg KO mice, can be used to study human hepatocyte regeneration. After transplantation of human hepatocytes, these mice can develop "humanized livers", which are of significant importance for research in liver biology, stem cells, infectious diseases, metabolism, and gene therapy.
Application Area
Research on tyrosinemia Type I (HT1)
Research on liver biology and liver-related drugs
Human liver regeneration and reconstruction
Stem cell, infectious disease, metabolism, and gene therapy
Validation Data