Epx-iCre mice were generated using gene editing technology to integrate an iCre-FRT-Neo-FRT-IRES expression cassette into the upstream of the ATG start codon of the mouse endogenous Epx gene. Under the control of the Epx gene's regulatory elements, the iCre recombinase (a codon-optimized Cre recombinase) is expressed. The FRT-Neo-FRT element is used to screen positive clones during the construction process, and the mice delivered to the customer have completed self-deletion of the Neo element. When Epx-iCre mice are crossed with mice containing loxP sites, Cre recombinase-mediated sequence recombination between loxP sites is expected to occur in Epx-positive cells of the offspring.