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G129 (Ifngr1 KO)
Product ID:
I001200
Background:
129S2/SvPasCya
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Strain Description
The G129 (Ifngr1 KO) mice on a 129 background are a type II (γ) interferon receptor (Ifngr1) gene knockout model. The absence of the IFNGR1 protein in these mice results in defective gamma interferon receptor function, which reduces natural resistance and may increase susceptibility to certain viral infections. Homozygous G129 (Ifngr1 KO) mice are viable and fertile.
Application Area
Area
Investigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV
Area
Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
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