BALB/c;B6J-Rosa26-hHRAS
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Age
Genotype
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Basic Information
Model Name
BALB/c;B6J-Rosa26-hHRAS
Product ID
I001214
Gene Name
Background
BALB/c;B6JCya
Gene Alias
CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
Classification
Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
11
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Note: When using this mouse strain in a publication, please cite “BALB/c;B6J-Rosa26-hHRAS mice (Catalog I001214) were purchased from Cyagen.”
Strain Description
BALB/c;B6J-Rosa26-hHRAS mice are obtained by crossing Rosa26-hHRAS mice on a C57BL/6JCya background (Catalog No.: I001213) with BALB/cAnCya mice. This hybrid strain exhibits higher sensitivity to both genotoxic and non-genotoxic human carcinogens. BALB/c;B6J-Rosa26-hHRAS mice can be used for rapid in vivo testing of the carcinogenicity of genotoxic and non-genotoxic compounds, studying the impact of HRAS oncogene point mutations on tumorigenesis and development, and developing tumor prevention or suppression therapies.
Application Area
Rapid in vivo test for carcinogenicity of genotoxic and non-genotoxic compounds
Impact of HRAS oncogene point mutations on tumorigenesis and development
Validation Data