C57BL/6JCya-Cacna1gem1flox/Cya
Common Name
Cacna1g-flox
Product ID
S-CKO-01491
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12291-Cacna1g-B6J-VA
When using this mouse strain in a publication, please cite “Cacna1g-flox Mouse (Catalog S-CKO-01491) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cacna1g-flox
Strain ID
CKOCMP-12291-Cacna1g-B6J-VA
Gene Name
Product ID
S-CKO-01491
Gene Alias
a1G, [a]1G, Cav3.1d, alpha-1G, mKIAA1123
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000100561
NCBI RefSeq
NM_009783
Target Region
Exon 2~4
Size of Effective Region
~1.3 kb
Overview of Gene Research
Cacna1g encodes the α1G subunit of the thalamus-enriched T-type calcium channel, also known as Ca(V)3.1, a low-threshold voltage-gated T-type calcium channel. This channel is involved in various cellular processes, especially those related to neural activity, and is crucial for normal neurological function [1,2].
In mouse models, reduced Cacna1g expression in Scn1a+/- Dravet syndrome mouse models led to partial amelioration of disease phenotypes, with improved survival and reduced spontaneous seizure frequency, suggesting Cacna1g is a genetic modifier in this syndrome [3]. In Scn2a(Q54) transgenic epilepsy mouse models, increased Cacna1g expression led to an increased spontaneous seizure frequency, while decreased expression led to a decreased seizure frequency, indicating Cacna1g as an epilepsy modifier gene [4].
In conclusion, Cacna1g plays a vital role in neural activity, especially in relation to epilepsy. The study of Cacna1g using gene-knockout (KO) and conditional-knockout (CKO) mouse models has provided valuable insights into its role in Dravet syndrome and other epilepsy-related conditions, highlighting its potential as a therapeutic target for these neurological disorders.
References：
1. Kim, Ji-Il, Miura, Yuki, Li, Min-Yin, Huguenard, John R, Pașca, Sergiu P. 2024. Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway. In Neuron, 112, 4048-4059.e7. doi:10.1016/j.neuron.2024.09.020. https://pubmed.ncbi.nlm.nih.gov/39419023/
2. De Riggi, Martina, De Giorgi, Agnese, Pollini, Luca, Galosi, Serena, Bologna, Matteo. 2024. CACNA1G Causes Dominantly Inherited Myoclonus-Ataxia with Intellectual Disability: A Case Report. In Cerebellum (London, England), 23, 2679-2683. doi:10.1007/s12311-024-01734-6. https://pubmed.ncbi.nlm.nih.gov/39287920/
3. Calhoun, Jeffrey D, Hawkins, Nicole A, Zachwieja, Nicole J, Kearney, Jennifer A. 2017. Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome. In Epilepsia, 58, e111-e115. doi:10.1111/epi.13811. https://pubmed.ncbi.nlm.nih.gov/28556246/
4. Calhoun, Jeffrey D, Hawkins, Nicole A, Zachwieja, Nicole J, Kearney, Jennifer A. 2016. Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a. In Epilepsia, 57, e103-7. doi:10.1111/epi.13390. https://pubmed.ncbi.nlm.nih.gov/27112236/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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