C57BL/6JCya-Cdh13em1flox/Cya
Common Name
Cdh13-flox
Product ID
S-CKO-01661
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12554-Cdh13-B6J-VA
When using this mouse strain in a publication, please cite “Cdh13-flox Mouse (Catalog S-CKO-01661) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cdh13-flox
Strain ID
CKOCMP-12554-Cdh13-B6J-VA
Gene Name
Product ID
S-CKO-01661
Gene Alias
Cdht, Tcad, 4932416G01Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000117160
NCBI RefSeq
NM_019707
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
CDH13, also known as T-cadherin or H-cadherin, is an atypical member of the cadherin family. It is a cell adhesion molecule anchored to the cell surface membrane via a glycosyl phosphatidyl inositol (GPI) moiety. CDH13 has been implicated in various biological processes, including axonal growth cone development, synapse morphogenesis, and embryonic neural tube formation. It may also be involved in regulating lipid metabolism during adipogenesis [3,4,5,6,7].
In a CDH13-deficient mouse model, early-life stress led to increased anxiety-like behavior compared to other genotypes, indicating a role of CDH13 in the programming of and adaptation to early-life stress [4]. In chronic myeloid leukemia (CML) cells, activation of CDH13 expression by small RNA promoted cell apoptosis by inhibiting the NF-κB signaling pathway, overcoming BCR-ABL1-independent resistance to imatinib [2]. In clear cell renal cell carcinoma (ccRCC), CDH13 was significantly upregulated and strongly correlated with better survival, lower cancer stages, and lower tumor grades [1].
In conclusion, CDH13 plays important roles in neurodevelopment, adipocyte differentiation, and cancer-related processes. Gene knockout mouse models have been crucial in revealing its functions in early-life stress adaptation, CML drug resistance, and ccRCC prognosis, providing insights into potential therapeutic targets and disease mechanisms.
References：
1. Shao, Yuan, Li, Wenxia, Zhang, Lin, Wang, Dongwen, Wu, Bo. 2022. CDH13 is a prognostic biomarker and a potential therapeutic target for patients with clear cell renal cell carcinoma. In American journal of cancer research, 12, 4520-4544. doi:. https://pubmed.ncbi.nlm.nih.gov/36381315/
2. Su, Rui, Wen, Ziqi, Zhan, Xingri, Su, Yubin, Fei, Jia. 2024. Small RNA activation of CDH13 expression overcome BCR-ABL1-independent imatinib-resistance and their signaling pathway studies in chronic myeloid leukemia. In Cell death & disease, 15, 615. doi:10.1038/s41419-024-07006-9. https://pubmed.ncbi.nlm.nih.gov/39179585/
3. Göddeke, Simon, Knebel, Birgit, Fahlbusch, Pia, Ouwens, D Margriet, Kotzka, Jorg. 2018. CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health. In International journal of obesity (2005), 42, 1039-1050. doi:10.1038/s41366-018-0022-4. https://pubmed.ncbi.nlm.nih.gov/29467502/
4. Kiser, Dominik P, Popp, Sandy, Schmitt-Böhrer, Angelika G, Lesch, Klaus-Peter, Rivero, Olga. 2018. Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice. In Progress in neuro-psychopharmacology & biological psychiatry, 89, 158-168. doi:10.1016/j.pnpbp.2018.08.010. https://pubmed.ncbi.nlm.nih.gov/30165120/
5. Takeuchi, T, Ohtsuki, Y. . Recent progress in T-cadherin (CDH13, H-cadherin) research. In Histology and histopathology, 16, 1287-93. doi:10.14670/HH-16.1287. https://pubmed.ncbi.nlm.nih.gov/11642747/
6. Gupta, Suruchi, Priya, Indu, Arora, Manu, Mahajan, Ritu, Kapoor, Nisha. 2023. Association of the CDH13 gene variant rs9940180 with schizophrenia risk in North Indian population. In American journal of translational research, 15, 6476-6485. doi:. https://pubmed.ncbi.nlm.nih.gov/38074818/
7. Rivero, Olga, Sich, Sarah, Popp, Sandy, Franke, Barbara, Lesch, Klaus-Peter. 2012. Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks. In European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23, 492-507. doi:10.1016/j.euroneuro.2012.06.009. https://pubmed.ncbi.nlm.nih.gov/22795700/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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