C57BL/6JCya-Cpt1bem1flox/Cya
Common Name:
Cpt1b-flox
Product ID:
S-CKO-01850
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cpt1b-flox
Strain ID
CKOCMP-12895-Cpt1b-B6J-VA
Gene Name
Product ID
S-CKO-01850
Gene Alias
Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cpt1bem1flox/Cya mice (Catalog S-CKO-01850) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000109313
NCBI RefSeq
NM_009948
Target Region
Exon 8~9
Size of Effective Region
~0.8 kb
Detailed Document
Overview of Gene Research
Cpt1b, short for carnitine palmitoyltransferase 1b, is a key rate-limiting enzyme in fatty acid metabolism [4]. It catalyzes the rate-limiting step of fatty acid oxidation, which is crucial for energy production in many tissues with high energy demands [3,5]. Cpt1b is involved in pathways such as the AMPK/PPARα pathway, which is related to lipid metabolism regulation [1].
In gene knockout studies, inactivation of Cpt1b in cardiomyocytes improves resistance to hypoxia and stimulates cardiomyocyte proliferation, enabling heart regeneration after ischaemia-reperfusion injury [2]. Knocking out entire cpt1b coding sequences in zebrafish leads to impaired cardiomyocyte proliferation [4]. In prostate cancer, silencing of Cpt1B results in downregulated cell proliferation, reduced S-phase distribution, and lower invasive ability [5]. In pancreatic cancer, silencing of Cpt1B suppresses the proliferative ability and metastasis of pancreatic cancer cells and enhances gemcitabine toxicity [6].
In conclusion, Cpt1b plays an essential role in fatty acid metabolism, influencing energy production in cells. Gene knockout models in mice, zebrafish, and cell-based studies have revealed its significance in heart regeneration, cancer cell proliferation, and metastasis. These findings suggest Cpt1b could be a potential therapeutic target for diseases such as heart injury and certain cancers [2,4,5,6].
References:
1. Wu, Liang, Liu, Changjie, Chang, Dong-Yuan, Zheng, Lemin, Chen, Min. 2021. The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway. In Diabetes, 70, 2192-2203. doi:10.2337/db21-0050. https://pubmed.ncbi.nlm.nih.gov/34103347/
2. Li, Xiang, Wu, Fan, Günther, Stefan, Yuan, Xuejun, Braun, Thomas. 2023. Inhibition of fatty acid oxidation enables heart regeneration in adult mice. In Nature, 622, 619-626. doi:10.1038/s41586-023-06585-5. https://pubmed.ncbi.nlm.nih.gov/37758950/
3. Ling, Qing, Mao, Shihui, Pan, Jiajia, Wang, Jinghan, Jin, Jie. . CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML. In Cancer biomarkers : section A of Disease markers, 37, 133-145. doi:10.3233/CBM-210043. https://pubmed.ncbi.nlm.nih.gov/36938722/
4. Cheng, Xiaohan, Ju, Jingyi, Huang, Wenping, Duan, Zongyi, Han, Yanchao. 2024. cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish. In Journal of cardiovascular development and disease, 11, . doi:10.3390/jcdd11110344. https://pubmed.ncbi.nlm.nih.gov/39590187/
5. Abudurexiti, Mierxiati, Zhu, Wenkai, Wang, Yuchen, Lin, Guowen, Ye, Dingwei. 2020. Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer. In The Prostate, 80, 950-961. doi:10.1002/pros.24027. https://pubmed.ncbi.nlm.nih.gov/32648618/
6. Tuerhong, Abudureyimu, Xu, Jin, Wang, Wei, Yu, Xianjun, Liang, Chen. 2024. CPT1B maintains redox homeostasis and inhibits ferroptosis to induce gemcitabine resistance via the KEAP1/NRF2 axis in pancreatic cancer. In Surgery, 175, 1264-1275. doi:10.1016/j.surg.2023.12.019. https://pubmed.ncbi.nlm.nih.gov/38302326/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen