C57BL/6JCya-Fgf1em1flox/Cya
Common Name
Fgf1-flox
Product ID
S-CKO-02396
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-14164-Fgf1-B6J-VA
When using this mouse strain in a publication, please cite “Fgf1-flox Mouse (Catalog S-CKO-02396) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Fgf1-flox
Strain ID
CKOCMP-14164-Fgf1-B6J-VA
Gene Name
Product ID
S-CKO-02396
Gene Alias
Fam, Fgfa, Dffrx, Fgf-1, Fgf2b
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 18
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000040647
NCBI RefSeq
NM_010197
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Overview of Gene Research
Fgf1, also known as acidic FGF (aFGF), is involved in the regulation of various biological processes, from development to disease pathogenesis. It is a single-chain polypeptide highly expressed in adult brain and kidney tissues. Fgf1 can regulate fatty acid homeostasis by suppressing adipose lipolysis through the FGF1/PDE4 pathway, and is also associated with metabolic regulation and anti-inflammatory and antioxidant effects in multiple tissues [1,2,4].
Fgf1 knockout mice exposed to a high-fat diet show an aggressive diabetic phenotype along with aberrant adipose tissue expansion, indicating its role in diabetes-related metabolic regulation [2]. In addition, in models of diabetic cardiomyopathy, the decrease in serum FGF1 levels is positively correlated with fraction shortening, and treatment with a FGF1 variant (FGF1∆HBS) can prevent diabetes-induced cardiac injury [3].
In conclusion, Fgf1 plays a crucial role in regulating metabolic processes, especially in relation to diabetes and related complications. Studies using gene knockout mouse models have revealed its importance in maintaining normal adipose-hepatic glucose production axis and protecting the heart from diabetes-induced damage, providing potential therapeutic targets for diabetes and its associated cardiomyopathy.
References：
1. Sancar, Gencer, Liu, Sihao, Gasser, Emanuel, Downes, Michael, Evans, Ronald M. . FGF1 and insulin control lipolysis by convergent pathways. In Cell metabolism, 34, 171-183.e6. doi:10.1016/j.cmet.2021.12.004. https://pubmed.ncbi.nlm.nih.gov/34986332/
2. Jamal, Sahar B, Hockman, Dorit. 2024. FGF1. In Differentiation; research in biological diversity, 139, 100802. doi:10.1016/j.diff.2024.100802. https://pubmed.ncbi.nlm.nih.gov/39074995/
3. Wang, Dezhong, Yin, Yuan, Wang, Shuyi, Li, Xiaokun, Huang, Zhifeng. 2021. FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression. In Signal transduction and targeted therapy, 6, 133. doi:10.1038/s41392-021-00542-2. https://pubmed.ncbi.nlm.nih.gov/33762571/
4. Dhlamini, Qhaweni, Wang, Wei, Feng, Guifeng, Zhang, Hailin, Zhang, Jin-San. 2022. FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress. In Molecular medicine (Cambridge, Mass.), 28, 73. doi:10.1186/s10020-022-00502-8. https://pubmed.ncbi.nlm.nih.gov/35764933/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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