C57BL/6JCya-Fxr1em1flox/Cya
Common Name:
Fxr1-flox
Product ID:
S-CKO-02506
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Fxr1-flox
Strain ID
CKOCMP-14359-Fxr1-B6J-VA
Gene Name
Product ID
S-CKO-02506
Gene Alias
1110050J02Rik; 9530073J07Rik; Fxr1h; Fxr1p
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fxr1em1flox/Cya mice (Catalog S-CKO-02506) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001620
NCBI RefSeq
NM_001113188
Target Region
Exon 8~9
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Fxr1, also known as Fragile X mental retardation autosomal 1, is an RNA-binding protein belonging to the Fragile X-related (FXR) family. It is crucial for development and plays significant roles in multiple biological processes such as gene expression regulation. It is involved in pathways related to translation, cell shape regulation, and may be associated with various disease-related pathways [1,2]. Genetic models, especially KO/CKO mouse models, are valuable for studying its functions.
Germline-specific Fxr1 ablation in mice impaired the translation of target mRNAs, causing defective spermatid development and male infertility, indicating its essential role in spermiogenesis [1]. In another aspect, point mutations in Fxr1, similar to those in its homolog FMR1 causing fragile X syndrome, disrupted the Fxr1 network which is necessary for RhoA signaling-induced actomyosin reorganization, affecting cell shape, migration, and synaptic function [2].
In conclusion, Fxr1 is vital for processes like spermiogenesis and actomyosin remodeling. The study of Fxr1 through KO/CKO mouse models has provided insights into its role in male infertility and processes related to cell shape and function, which are relevant in understanding associated diseases.
References:
1. Kang, Jun-Yan, Wen, Ze, Pan, Duo, Huang, Ying, Liu, Mo-Fang. 2022. LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs. In Science (New York, N.Y.), 377, eabj6647. doi:10.1126/science.abj6647. https://pubmed.ncbi.nlm.nih.gov/35951695/
2. Chen, Xiuzhen, Fansler, Mervin M, Janjoš, Urška, Ule, Jernej, Mayr, Christine. 2024. The FXR1 network acts as a signaling scaffold for actomyosin remodeling. In Cell, 187, 5048-5063.e25. doi:10.1016/j.cell.2024.07.015. https://pubmed.ncbi.nlm.nih.gov/39106863/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen